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Article
Open AccessFirst-line penpulimab (an anti-PD1 antibody) and anlotinib (an angiogenesis inhibitor) with nab-paclitaxel/gemcitabine (PAAG) in metastatic pancreatic cancer: a prospective, multicentre, biomolecular exploratory, phase II trial
Metastatic pancreatic cancer (mPC) has a dismal prognosis. Herein, we conducted a prospective, multicentre, single-arm, phase II trial evaluating the efficacy and safety of penpulimab and anlotinib in combinat...
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Article
Open AccessCrosstalk between metabolism and cell death in tumorigenesis
It is generally recognized that tumor cells proliferate more rapidly than normal cells. Due to such an abnormally rapid proliferation rate, cancer cells constantly encounter the limits of insufficient oxygen an...
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Article
Influence of phase-shifting error of phase-shifting interferometry on the phase accuracy recovery
To study the influence of phase-shifting error on phase accuracy recovery, we can reconstruct the wavefront by controlling the phase-shifting error of a certain step in the actual measurement, and the surface ...
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Article
Serum Cystatin C is a potential biomarker for predicting amyotrophic lateral sclerosis survival
Currently, it is unclear whether serum Cystatin C can be used to evaluate the prognosis of ALS. We aim to study the relationship between serum Cystatin C and survival in ALS.
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Article
Highly-selective Pt/PAA@MIL-125 Catalyst for Hydrosilylation of γ-(2,3-Epoxypropoxy) Trimethoxysilane
γ-(2,3-Epoxypropoxy) trimethoxysilane is a crucial silicone product synthesized by hydrosilylation. Its derived downstream silicone products have galvanized the development of silicone industry. However, the Sp.....
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Article
Mendelian Randomization Identifies Genetically Supported Drug Targets for Amyotrophic Lateral Sclerosis and Frontotemporal Dementia
Currently, amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) have no effective treatments. Drug repurposing offers a rapid method to meet therapeutic need for ALS and FTD. To identify thera...
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Article
Evaluating the causal association between microRNAs and amyotrophic lateral sclerosis
Currently, miRNAs are involved in the development of amyotrophic lateral sclerosis (ALS), and identifying circulating miRNAs that are causally associated with ALS risk as biomarkers is imperative.
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Article
Open AccessGenetically proxied antidiabetic drugs targets and stroke risk
Previous studies have assessed the association between antidiabetic drugs and stroke risk, but the results are inconsistent. Mendelian randomization (MR) was used to assess effects of antidiabetic drugs on str...
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Article
Open AccessHypertension, antihypertensive drugs, and age at onset of Huntington’s disease
Associations between blood pressure (BP) with age at onset of Huntington’s disease (HD) have reported inconsistent findings. We used Mendelian randomization (MR) to assess effects of BP and lowering systolic B...
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Article
Assessing the association between white matter lesions and Parkinson’s disease
The association between white matter (WM) lesions and Parkinson’s disease (PD) was not fully established. We therefore applied Mendelian randomization (MR) analyses to identify the causal effect between white ...
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Article
Open AccessPosttranslational control of lipogenesis in the tumor microenvironment
Metabolic reprogramming of cancer cells within the tumor microenvironment typically occurs in response to increased nutritional, translation and proliferative demands. Altered lipid metabolism is a marker of t...
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Chapter and Conference Paper
Supervision System on Construction and Demolition Waste Recycling: Lessons from Shenzhen, Hangzhou and Chongqing, China
A large amount of construction and demolition waste is generated owing to the rapid development of the construction industry. Of all the countries in the world, China produces the largest amount of constructio...
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Chapter and Conference Paper
Comparative Analysis of National Policies on Construction and Demolition Waste Management in China and Japan
In the age of greater environmental awareness, sustainable development in construction sector could be very significant. Despite of increasing awareness of recycling by industry, the practice of construction a...
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Article
LINC00265 promotes colorectal tumorigenesis via ZMIZ2 and USP7-mediated stabilization of β-catenin
Colorectal cancer (CRC) is the third most prevalent world cancer and oncogenic β-catenin is frequently dysregulated in CRC. Long noncoding RNAs (lncRNAs) play critical roles in colorectal tumorigenesis; howeve...
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Article
Stabilization of FASN by ACAT1-mediated GNPAT acetylation promotes lipid metabolism and hepatocarcinogenesis
Metabolic alteration for adaptation of the local environment has been recognized as a hallmark of cancer. GNPAT dysregulation has been implicated in hepatocellular carcinoma (HCC). However, the precise posttra...
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Article
miR-148a inhibits colitis and colitis-associated tumorigenesis in mice
miR-148a has been shown to regulate inflammation, immunity and the growth of certain tumors, but its roles in colitis and colorectal tumorigenesis remain largely undetermined. Here we found miR-148a-deficient ...
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Article
Open AccessMicroRNA-148a deficiency promotes hepatic lipid metabolism and hepatocarcinogenesis in mice
miRNAs are involved in many physiologic and disease processes by virtue of degrading specific mRNAs or inhibiting their translation. miR-148a has been implicated in the control of tumor growth and cholesterol ...
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Chapter and Conference Paper
Applying STIRPAT Model to Identify Driving Factors of Urban Residential Building Energy Consumption: A Case Study of Chongqing in China
In this article population, urbanization, construction area and the level of urban consumption are selected as the key factors of driving the growth of urban residential building energy consumption. At the sam...
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Chapter and Conference Paper
An efficient distributed algorithm for finding articulation points, Bridges, and biconnected components in asynchronous networks
