2,170 Result(s)

Article

Correction: Pyrroloquinoline quinone promotes human mesenchymal stem cell-derived mitochondria to improve premature ovarian insufficiency in mice through the SIRT1/ATM/p53 pathway

Shengjie Liu, Yuanmei Wang, Hanlin Yang, Jun Tan… in Stem Cell Research & Therapy (2024)

Article

Dexmedetomidine and argon in combination against ferroptosis through tackling TXNIP-mediated oxidative stress in DCD porcine livers

Graft availability from donation after circulatory death (DCD) is significantly limited by ischaemia reperfusion (IR) injury. Effective strategies to mitigate IR injury in DCD grafts are essential to improve g...

Qian Chen, Jiashi Sun, **angfeng Liu, Zhigang Qin, Jieyu Li… in Cell Death Discovery (2024)

Article

Publisher Correction: Restrained Mitf-associated autophagy by Mulberroside A ameliorates osteoclastogenesis and counteracts OVX-Induced osteoporosis in mice

Hong Xue, Zhenhua Feng, Putao Yuan, Li Qiao, Qiliang Lou… in Cell Death Discovery (2024)

Article

The combination of temozolomide and perifosine synergistically inhibit glioblastoma by impeding DNA repair and inducing apoptosis

Temozolomide (TMZ) is widely utilized as the primary chemotherapeutic intervention for glioblastoma. However, the clinical use of TMZ is limited by its various side effects and resistance to chemotherapy. The ...

Wenpeng Zhao, Liwei Zhou, Wentao Zhao, Huiying Yang, Zhenwei Lu… in Cell Death Discovery (2024)

Article

New advances in drug development for metabolic dysfunction-associated diseases and alcohol-associated liver disease

Metabolic disorders are currently threatening public health worldwide. Discovering new targets and develo** promising drugs will reduce the global metabolic-related disease burden. Metabolic disorders primar...

**ming Zhang, Yixin Li, Liu Yang, Ningning Ma, Shengying Qian… in Cell & Bioscience (2024)

Article

Distraction force promotes the osteogenic differentiation of Gli1⁺ cells in facial sutures via primary cilia-mediated Hedgehog signaling pathway

Trans-sutural distraction osteogenesis (TSDO) involves the application of distraction force to facial sutures to stimulate osteogenesis. Gli1⁺ cells in the cranial sutures play an important role in bone growth. H...

Mengying **, Yang An, Zheng Wang, Guanhuier Wang… in Stem Cell Research & Therapy (2024)

Article

Publisher Correction: LINC317.5 as a novel biomarker for hypertriglyceridemia in abnormal glucose metabolism

Yixue Yang, Mengzi Sun, Shoumeng Yan, Nan Yao, **aotong Li… in Cell Death Discovery (2024)

Article

Correction: Dysfunction of ATG7-dependent autophagy dysregulates the antioxidant response and contributes to oxidative stress-induced biological impairments in human epidermal melanocytes

Zhuhui Qiao, Zhongyi Xu, Qing **ao, Yiwen Yang, Jiayi Ying… in Cell Death Discovery (2024)

Article

The emerging role of nuclear receptor coactivator 4 in health and disease: a novel bridge between iron metabolism and immunity

Nuclear receptor coactivator 4 (NCOA4) has recently been recognized as a selective cargo receptor of ferritinophagy participating in ferroptosis. However, NCOA4 is also a coactivator that modulates the transcr...

Yue Le, Qinjie Liu, Yi Yang, Jie Wu in Cell Death Discovery (2024)

Article

Research progress and prospects of benefit-risk assessment methods for umbilical cord mesenchymal stem cell transplantation in the clinical treatment of spinal cord injury

Over the past decade, we have witnessed the development of cell transplantation as a new strategy for repairing spinal cord injury (SCI). However, due to the complexity of the central nervous system (CNS), ach...

Ruoqi Shen, Yubao Lu, Chaoyang Cai, Ziming Wang, Jiayu Zhao… in Stem Cell Research & Therapy (2024)

Article

Mesenteric lymph nodes: a critical site for the up-regulatory effect of hUC-MSCs on Treg cells by producing TGF-β1 in colitis treatment

Mesenchymal stem cells (MSCs) demonstrate a wide range of therapeutic capabilities in the treatment of inflammatory bowel disease (IBD). The intraperitoneal injection of MSCs has exhibited superior therapeutic...

Qixiang Zhang, Zhu Zeng, Ning Wei, Yueyan Su, **g Wang… in Stem Cell Research & Therapy (2024)

Article

A pan-KRAS degrader for the treatment of KRAS-mutant cancers

KRAS mutations are highly prevalent in a wide range of lethal cancers, and these mutant forms of KRAS play a crucial role in driving cancer progression and conferring resistance to treatment. While there have bee...

Jie Yang, Qiao-Li Wang, Guan-Nan Wang, Jia-Cong Ye, Zi-Qian Li… in Cell Discovery (2024)

Article

Mobilization and activation of tumor-infiltrating dendritic cells inhibits lymph node metastasis in intrahepatic cholangiocarcinoma

Lymph node metastasis (LNM) facilitates distant tumor colonization and leads to the high mortality in patients with intrahepatic cholangiocarcinoma (ICC). However, it remains elusive how ICC cells subvert immu...

Bao-Ye Sun, Zhu-Tao Wang, Ke-Zhu Chen, Yang Song, **g-Fang Wu… in Cell Death Discovery (2024)

Article

Structural and functional insights into the helicase protein E5 of Mpox virus

Mpox virus (MPXV) can cause mpox in humans. Due to its quick and wide spread in the past two years, mpox has turned into a significant public health concern. Helicase E5 is a multi-domain protein; its primer s...

Weizhen Zhang, Yusong Liu, Mengquan Yang, Jie Yang, Zhiwei Shao… in Cell Discovery (2024)

Article

Molecular recognition of the atypical chemokine-like peptide GPR15L by its cognate receptor GPR15

Zhongyuan Zhang, You Zheng, Lu Xu, Yang Yue, Kexin Xu, Fei Li, Fei Xu in Cell Discovery (2024)

Article

LIMA1 links the E3 ubiquitin ligase RNF40 to lipid metabolism

LIMA1 is a LIM domain and Actin binding 1 protein that acts as a skeleton protein to promote cholesterol absorption, which makes it an ideal target for interfering with lipid metabolism. However, the detailed ...

Zhan Liu, Kexin Fan, Aikedaimu Abudukeremu, Min Gao, **nyue Tan… in Cell Death Discovery (2024)

Article

CCL11 released by GSDMD-mediated macrophage pyroptosis regulates angiogenesis after hindlimb ischemia

Peripheral vascular disease (PVD) is an emerging public health burden with a high rate of disability and mortality. Gasdermin D (GSDMD) has been reported to exert pyroptosis and play a critical role in the pat...

Yiwen Wang, Yang Gao, Huairui Shi, Rifeng Gao, Ji’e Yang, Ya’nan Qu… in Cell Death Discovery (2024)

Article

TMC6 functions as a GPCR-like receptor to sense noxious heat via Gαq signaling

Thermosensation is vital for the survival, propagation, and adaption of all organisms, but its mechanism is not fully understood yet. Here, we find that TMC6, a membrane protein of unknown function, is highly ...

Chen Zhang, Fang Tong, Bin Zhou, Mingdong He, Shuai Liu, **aomeng Zhou… in Cell Discovery (2024)

Article

Insights into the role of mesenchymal stem cells in cutaneous medical aesthetics: from basics to clinics

With the development of the economy and the increasing prevalence of skin problems, cutaneous medical aesthetics are gaining more and more attention. Skin disorders like poor wound healing, aging, and pigmenta...

Junyi Li, Ye Liu, Rui Zhang, Qianyu Yang, Wei **ong, Yan He… in Stem Cell Research & Therapy (2024)

Article

LncRNA SNHG1 enhances cartilage regeneration by modulating chondrogenic differentiation and angiogenesis potentials of JBMMSCs via mitochondrial function regulation

Cartilage is a kind of avascular tissue, and it is difficult to repair itself when it is damaged. In this study, we investigated the regulation of chondrogenic differentiation and vascular formation in human j...

Hua Liu, Huina Liu, Qiubo Yang, Zhipeng Fan in Stem Cell Research & Therapy (2024)