7 Result(s)
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Article
Cora S Thiel
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Open AccessExpression of hypoxia-inducible genes is suppressed in altered gravity due to impaired nuclear HIF1α accumulation
Extravehicular activities, the backbone of manned space exploration programs, set astronauts into mild hypoxia. Unfortunately, microgravity aggravates threatening symptoms of hypoxia such as vision impairment ...
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Open AccessRapid coupling between gravitational forces and the transcriptome in human myelomonocytic U937 cells
The gravitational force has been constant throughout Earth’s evolutionary history. Since the cell nucleus is subjected to permanent forces induced by Earth’s gravity, we addressed the question, if gene express...
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Open AccessStability of gene expression in human T cells in different gravity environments is clustered in chromosomal region 11p15.4
In the last decades, a plethora of in vitro studies with living human cells contributed a vast amount of knowledge about cellular and molecular effects of microgravity. Previous studies focused mostly on the i...
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Open AccessDynamic gene expression response to altered gravity in human T cells
We investigated the dynamics of immediate and initial gene expression response to different gravitational environments in human Jurkat T lymphocytic cells and compared expression profiles to identify potential...
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Open AccessRapid adaptation to microgravity in mammalian macrophage cells
Despite the observed severe effects of microgravity on mammalian cells, many astronauts have completed long term stays in space without suffering from severe health problems. This raises questions about the ce...
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Open AccessRapid alterations of cell cycle control proteins in human T lymphocytes in microgravity
In our study we aimed to identify rapidly reacting gravity-responsive mechanisms in mammalian cells in order to understand if and how altered gravity is translated into a cellular response. In a combination of...
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A readily retrievable pool of synaptic vesicles
Because clathrin-mediated endocytosis (CME) is relatively slow, it's been suggested that a readily retrievable pool of synaptic vesicle proteins might support fast CME. The authors use a recently developed pro...
