184 Result(s)
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HIV-specific cytotoxic T-cells in HIV-exposed but uninfected Gambian women
A crucial requirement in the rational design of a prophylactic vaccine against the hu-uman immunodeficiency virus (HIV) is to establish whether or not protective immunity can occur following natural infection....
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Immunoprophylaxis of allergen–induced immunoglobulin E synthesis and airway hyperresponsiveness in vivo by genetic immunization
The efficacy of an “allergen–gene immunization protocol” in altering allergic response was examined. Intramuscular injection of rats with a plasmid DNA encoding a house dust mite allergen into the muscle resul...
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Protective mucosal immunity elicited by targeted iliac lymph node immunization with a subunit SIV envelope and core vaccine in macaques
Prevention of sexually transmitted HIV infection was investigated in macaques by immunization with a recombinant SIV (simian immunodeficiency virus) envelope gp120 and core p27 vaccine. In two independent seri...
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Reply to “SIV and HIV prophylaxis”
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Multiple kinetic components of exocytosis distinguished by neurotoxin sensitivity
The secretion of synaptic and other vesicles is a complex process involving multiple steps. Many molecular components of the secretory apparatus have been identified, but how they relate to the different stage...
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Allo-immunization elicits CD8+ T cell-derived chemokines, HIV suppressor factors and resistance to HIV infection in women
We assessed the potential for an allogeneic-based vaccine against HIV infection in women who were allo-immunized with their partners' mononuclear leucocytes to prevent spontaneous recurrent abortion. Within 1 ...
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Visual input induces long-term potentiation of develo** retinotectal synapses
Early visual experience is essential in the refinement of develo** neural connections. In vivo whole-cell recording from the tectum of Xenopus tadpoles showed that repetitive dimming-light stimulation applied t...
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Stem cell repopulation efficiency but not pool size is governed by p27kip1
Sustained blood cell production requires preservation of a quiescent, multipotential stem cell pool that intermittently gives rise to progenitors with robust proliferative potential. The ability of cells to sh...
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Probing ion permeation and gating in a K+ channel with backbone mutations in the selectivity filter
Potassium channels selectively conduct K+ ions across cell membranes, and use diverse mechanisms to control their gating. We studied ion permeation and gating of an inwardly rectifying K+ channel by individually ...
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Role of the chemokine SDF-1 as the meningeal attractant for embryonic cerebellar neurons
Migration of neuronal precursor cells from the external germinal layer (EGL) to the internal granular layer (IGL) is a crucial process in the development of the mammalian cerebellar cortex. These cells make up...
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Differential regulation of synaptic and extra-synaptic NMDA receptors
A variety of processes limit NMDA (N-methyl-D-aspartate) receptor (NMDAR) activity in response to agonist exposure, including rundown—the decline of peak current with repeated, sustained agonist application1,2,3,
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CDK4 coexpression with Ras generates malignant human epidermal tumorigenesis
Ras acts with other proteins to induce neoplasia. By itself, however, strong Ras signaling can suppress proliferation of normal cells. In primary epidermal cells, we found that oncogenic Ras transiently decrea...
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Deletion of cytosolic phospholipase A2 promotes striated muscle growth
Generation of arachidonic acid by the ubiquitously expressed cytosolic phospholipase A2 (PLA2) has a fundamental role in the regulation of cellular homeostasis, inflammation and tumorigenesis. Here we report that...
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Original antigenic sin and apoptosis in the pathogenesis of dengue hemorrhagic fever
Dengue virus presents a growing threat to public health in the develo** world. Four major serotypes of dengue virus have been characterized, and epidemiological evidence shows that dengue hemorrhagic fever (...
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Erratum: Deletion of cytosolic phospholipase A2 promotes striated muscle growth
Nat. Med. 9, 944–951 (2003) In the version of this article initially published online, the last sentence of the 'Isolation of Plag4a−/− and wild-type glomerular mesangial cells' section of the Methods containe...
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Soluble endoglin contributes to the pathogenesis of preeclampsia
Preeclampsia is a pregnancy-specific hypertensive syndrome that causes substantial maternal and fetal morbidity and mortality. Maternal endothelial dysfunction mediated by excess placenta-derived soluble VEGF ...
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Molecular approaches to brain asymmetry and handedness
The left and right hemispheres of the human brain have distinct functions: for example, the left is normally dominant for language and logical processing, wher...
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The virtue of simplicity
Multiple local motions must be combined to determine the direction of object motion, which is harder than it seems. A new paper proposes an elegant and simple solution to this problem, eminently realizable in ...
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Hdac2 regulates the cardiac hypertrophic response by modulating Gsk3β activity
In the adult heart, a variety of stresses induce re-expression of a fetal gene program in association with myocyte hypertrophy and heart failure. Here we show that histone deacetylase-2 (Hdac2) regulates expre...
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Deacetylase inhibition promotes the generation and function of regulatory T cells
Histone/protein deacetylases (HDACs) regulate chromatin remodeling and gene expression as well as the functions of more than 50 transcription factors and nonhistone proteins. We found that administration of an...
