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  1. No Access

    Article

    Differential regulation of myeloid leukemias by the bone marrow microenvironment

    Alteration of the bone marrow microenvironment by activation of the parathyroid hormone receptor attenuates chronic myelogenous leukemia (CML) but enhances acute myeloid leukemia (AML) in mouse models, suggest...

    Daniela S Krause, Keertik Fulzele, André Catic, Chia Chi Sun… in Nature Medicine (2013)

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    Article

    Stem cell repopulation efficiency but not pool size is governed by p27kip1

    Sustained blood cell production requires preservation of a quiescent, multipotential stem cell pool that intermittently gives rise to progenitors with robust proliferative potential. The ability of cells to sh...

    Tao Cheng, Neil Rodrigues, David Dombkowski, Sebastian Stier… in Nature Medicine (2000)

  3. No Access

    Article

    Pulsed electric fields for selection of hematopoietic cells and depletion of tumor cell contaminants

    Purging of tumor cells and selection of stem cells are key technologies for enabling stem cell transplantation and stem cell gene therapy. Here we report a strategy for cell selection based on physical propert...

    Henry M. Eppich, Russell Foxall, Kate Gaynor, David Dombkowski… in Nature Biotechnology (2000)