94 Result(s)
within
Science, Humanities and Social Sciences, multidisciplinary
**ao-liang Wang
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Open AccessControlled intracellular self-assembly of gadolinium nanoparticles as smart molecular MR contrast agents
Herein we developed a new “smart” Gd-based MR contrast agent (i.e., 1) which is susceptive to furin, a protease overexpressed in tumor. Under the action of furin, 1 condenses to form dimers (1-Ds) and the latt...
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Open AccessGenome of the Chinese tree shrew
Chinese tree shrews (Tupaia belangeri chinensis) possess many features valuable in animals used as experimental models in biomedical research. Currently, there are numerous attempts to employ tree shrews as model...
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Open AccessDEVD-Based Hydrogelator Minimizes Cellular Apoptosis Induction
Herein, we report the rational design of a DEVD-based heptapeptide hydrogelator 1 which is susceptible to caspase-3 (CASP3) and its isomeric control hydrogelator 2 with a DEDV-based heptapeptide sequence. Self...
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Open AccessSpin memristive magnetic tunnel junctions with CoO-ZnO nano composite barrier
The spin memristive devices combining memristance and tunneling magnetoresistance have promising applications in multibit nonvolatile data storage and artificial neuronal computing. However, it is a great chal...
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Open AccessWASH complex regulates Arp2/3 complex for actin-based polar body extrusion in mouse oocytes
Prior to their fertilization, oocytes undergo asymmetric division, which is regulated by actin filaments. Recently, WASH complex were identified as actin nucleation promoting factors (NPF) that activated Arp2/...
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Open AccessControl of cotton fibre elongation by a homeodomain transcription factor GhHOX3
Cotton fibres are unusually long, single-celled epidermal seed trichomes and a model for plant cell growth, but little is known about the regulation of fibre cell elongation. Here we report that a homeodomain-...
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Open AccessUtilisation of adsorption and desorption for simultaneously improving protein crystallisation success rate and crystal quality
High-quality protein crystals of suitable size are an important prerequisite for applying X-ray crystallography to determine the 3-dimensional structure of proteins. However, it is often difficult to obtain pr...
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Open AccessBiomimetic synthesis of struvite with biogenic morphology and implication for pathological biomineralization
Recent studies have found that certain urinary proteins can efficiently inhibit stone formation. These discoveries are significant for develo** effective therapies for stone disease, but the inhibition mecha...
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Open AccessHelical Growth of Aluminum Nitride: New Insights into Its Growth Habit from Nanostructures to Single Crystals
By understanding the growth mechanism of nanomaterials, the morphological features of nanostructures can be rationally controlled, thereby achieving the desired physical properties for specific applications. H...
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Open AccessPAQR3 modulates cholesterol homeostasis by anchoring Scap/SREBP complex to the Golgi apparatus
Cholesterol biosynthesis is regulated by transcription factors SREBPs and their escort protein Scap. On sterol depletion, Scap/SREBP complex is transported from endoplasmic reticulum (ER) to the Golgi apparatu...
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Open AccessHydrogel Walkers with Electro-Driven Motility for Cargo Transport
In this study, soft hydrogel walkers with electro-driven motility for cargo transport have been developed via a facile mould-assisted strategy. The hydrogel walkers consisting of polyanionic poly(2-acrylamido-2-m...
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Open AccessGossypium barbadense genome sequence provides insight into the evolution of extra-long staple fiber and specialized metabolites
Of the two cultivated species of allopolyploid cotton, Gossypium barbadense produces extra-long fibers for the production of superior textiles. We sequenced its genome (AD)2 and performed a comparative analysis. ...
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Open AccessMethylation-mediated BMPER expression in fibroblast activation in vitro and lung fibrosis in mice in vivo
Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease. Although the pathogenesis is poorly understood, evidence suggests that genetic and epigenetic alterations, such as DNA methylation, may play a...
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Open AccessStimulation of autophagy promotes functional recovery in diabetic rats with spinal cord injury
In this study we examined the relationship between autophagy and apoptosis in diabetic rats after spinal cord injury (SCI), also we determined the role of autophagy in diabetes-aggravated neurological injury in v...
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Open AccessGiant barocaloric effect in hexagonal Ni2In-type Mn-Co-Ge-In compounds around room temperature
The most widespread cooling techniques based on gas compression/expansion encounter environmental problems. Thus, tremendous effort has been dedicated to develop alternative cooling technique and search for so...
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Open AccessBt proteins Cry1Ah and Cry2Ab do not affect cotton aphid Aphis gossypii and ladybeetle Propylea japonica
Plant varieties expressing the Bt (Bacillus thuringiensis) insecticidal proteins Cry1Ah and Cry2Ab have potential commercialization prospects in China. However, their potential effects on non-target arthropods (N...
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Open AccessOsteoclast-derived exosomal miR-214-3p inhibits osteoblastic bone formation
Emerging evidence indicates that osteoclasts direct osteoblastic bone formation. MicroRNAs (miRNAs) have a crucial role in regulating osteoclast and osteoblast function. However, whether miRNAs mediate osteocl...
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Open AccessCorrection: Corrigendum: Giant barocaloric effect in hexagonal Ni2In-type Mn-Co-Ge-In compounds around room temperature
Scientific Reports 5: Article number: 18027; published online: 17 December 2015; updated: 29 March 2016 This Article contains errors. In the legend of Figure 3. "(a) Temperature dependence of heat flow (blue, ...
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Open AccessEffects of hydrogen-rich water on depressive-like behavior in mice
Emerging evidence suggests that neuroinflammation and oxidative stress may be major contributors to major depressive disorder (MDD). Patients or animal models of depression show significant increase of proinfl...
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Open AccessRegnase-1 in microglia negatively regulates high mobility group box 1-mediated inflammation and neuronal injury
Extracellular high mobility group box 1 (HMGB1) has been demonstrated to function as a proinflammatory cytokine and induces neuronal injury in response to various pathological stimuli in central nervous system...
