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Open AccessFibrinolytic niche is required for alveolar type 2 cell-mediated alveologenesis via a uPA-A6-CD44+-ENaC signal cascade
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Hyaluronan and TLR4 promote surfactant-protein-C-positive alveolar progenitor cell renewal and prevent severe pulmonary fibrosis in mice
Reduced hyaluronan–TLR4 signaling in a stem cell population of the lung contributes to a lack of renewal of these cells and promotes fibrosis in patients with idiopathic pulmonary fibrosis.
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Open AccessDown-regulation of USP13 mediates phenotype transformation of fibroblasts in idiopathic pulmonary fibrosis
Idiopathic pulmonary fibrosis (IPF) is a fatal disease characterized by fibroblastic foci and progressive scarring of the pulmonary parenchyma. IPF fibroblasts display increased proliferation and enhanced migr...
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Article
Open AccessMethylation-mediated BMPER expression in fibroblast activation in vitro and lung fibrosis in mice in vivo
Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease. Although the pathogenesis is poorly understood, evidence suggests that genetic and epigenetic alterations, such as DNA methylation, may play a...
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Article
The role of Toll-like receptors in non-infectious lung injury
The role of Toll-like receptors (TLRs) in pathogen recognition has been expeditiously advanced in recent years. However, investigations into the function of TLRs in non-infectious tissue injury have just begun...
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Chapter
Innate Immune Regulation of Lung Injury and Repair
Mechanisms that regulate host defense to noninfectious tissue injury are poorly understood. Here we summarize our recent work investigating the role of the innate immune response in regulating the inflammatory...
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Article
Regulation of lung injury and repair by Toll-like receptors and hyaluronan
Mechanisms that regulate inflammation and repair after acute lung injury are incompletely understood. The extracellular matrix glycosaminoglycan hyaluronan is produced after tissue injury and impaired clearanc...
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Article
Defective cleavage of membrane bound TGFα leads to enhanced activation of the EGF receptor in malignant cells
Transforming growth factor α (TGFα) is widely expressed in malignant as well as normal cells and is involved in regulating cell growth and differentiation. Although processing of TGFα has been extensively stud...
