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Article
Open AccessIFRD1 promotes tumor cells “low-cost” survival under glutamine starvation via inhibiting histone H1.0 nucleophagy
Glutamine addiction represents a metabolic vulnerability of cancer cells; however, effective therapeutic targeting of the pathways involved remains to be realized. Here, we disclose the critical role of interf...
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Article
The design and implementation of a teaching and learning analytics tool in a face-to-face, small-sized course in China’s higher education
The data-intensive research paradigm calls for using educational and learning data to generate actionable insights and improve the instruction and learning quality. Although previous research designed and empl...
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Article
Using an integrated probabilistic clustering approach to detect student engagement across asynchronous and synchronous online discussions
Online collaborative discussion (OCD) focuses on promoting individual knowledge inquiry and group knowledge construction through active peer interactions and communications. In practice, it is necessary to exp...
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Article
Open AccessDisplacement Calibration of Optical Tweezers With Gravitational Acceleration
In recent years, levitated particles of optical traps in vacuum have shown the enormous potential for precision sensor development and new physics exploration. However, the accuracy of the sensor is still hamp...
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Article
Open AccessPlant immunity suppression by an exo-β-1,3-glucanase and an elongation factor 1α of the rice blast fungus
Fungal cell walls undergo continual remodeling that generates β-1,3-glucan fragments as products of endo-glycosyl hydrolases (GHs), which can be recognized as pathogen-associated molecular patterns (PAMPs) and...
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Article
Open AccessHepatic vessel segmentation based on 3D swin-transformer with inductive biased multi-head self-attention
Segmentation of liver vessels from CT images is indispensable prior to surgical planning and aroused a broad range of interest in the medical image analysis community. Due to the complex structure and low-cont...
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Article
Open AccessNIPSNAP1 directs dual mechanisms to restrain senescence in cancer cells
Although the executive pathways of senescence are known, the underlying control mechanisms are diverse and not fully understood, particularly how cancer cells avoid triggering senescence despite experiencing e...
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Article
Long non-coding RNAs: definitions, functions, challenges and recommendations
Genes specifying long non-coding RNAs (lncRNAs) occupy a large fraction of the genomes of complex organisms. The term ‘lncRNAs’ encompasses RNA polymerase I (Pol I), Pol II and Pol III transcribed RNAs, and RN...
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Article
Open AccessSestrin2-mediated disassembly of stress granules dampens aerobic glycolysis to overcome glucose starvation
Sestrins are a small gene family of pleiotropic factors whose actions promote cell adaptation to a range of stress conditions. In this report we disclose the selective role of Sestrin2 (SESN2) in dampening aer...
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Article
Drops in the cell ocean: new roles for non-coding RNAs in liquid–liquid phase separation
Many types of membraneless organelles and related substructures occur in the nucleus and cytoplasm of cells, providing the essential framework for regulating innumerable biological activities. Fundamentally, t...
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Article
Open AccessIntegration of artificial intelligence performance prediction and learning analytics to improve student learning in online engineering course
As a cutting-edge field of artificial intelligence in education (AIEd) that depends on advanced computing technologies, AI performance prediction model is widely used to identify at-risk students that tend to ...
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Article
Engineered Spindles of Little Molecules Around Electrospun Nanofibers for Biphasic Drug Release
Biphasic drug release is a popular advanced drug controlled release profile that has been drawing increasing attention from many fields. Electrospun nanofibers and their derivatives can be act as a strong plat...
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Article
Open AccessHuman umbilical cord mesenchymal stem cell promotes angiogenesis via integrin β1/ERK1/2/HIF-1α/VEGF-A signaling pathway for off-the-shelf breast tissue engineering
Mesenchymal stem cells (MSC)-based tissue engineered breast represent the visible future for breast reconstruction after mastectomy. However, autologous MSCs might not be appropriate for the large graft constr...
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Article
Open AccessResha** the binding channel of a novel GH113 family β-mannanase from Paenibacillus cineris (PcMan113) for enhanced activity
Endo-β-mannanases are important enzymes for degrading lignocellulosic biomass to generate mannan, which has significant health effects as a prebiotic that promotes the development of gut microbiota. Here, a no...
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Article
A bean common mosaic virus-resistance gene in the soybean variant V94-5152 was mapped to the Rsv4 locus conferring resistance to soybean mosaic virus
In the soybean variant V94-5152, a BCMV-resistance gene was mapped near to the region of SMV-resistance Rsv4 locus, raising a possibility that V94-5152 may rely on Rsv4 locus to resist against both SMV and BCMV.
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Article
JAB1 promotes palmitate-induced insulin resistance via ERK pathway in hepatocytes
Insulin resistance (IR) is the primary pathological mechanism underlying Type 2 diabetes mellitus (T2DM). Many researches have reported the relationship between chronic inflammation and IR, while the extracell...
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Article
Open AccessControl of fibroblast shape in sequentially formed 3D hybrid hydrogels regulates cellular responses to microenvironmental cues
Cell shape plays important roles in regulating cell behavior; however, independently controlling cell shape in three dimensions is a challenging undertaking, and how cell shape affects cellular responses to me...
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Article
Open AccessAurora-A mediated phosphorylation of LDHB promotes glycolysis and tumor progression by relieving the substrate-inhibition effect
Overexpressed Aurora-A kinase promotes tumor growth through various pathways, but whether Aurora-A is also involved in metabolic reprogramming-mediated cancer progression remains unknown. Here, we report that ...
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Article
Molecular map** of the gene(s) conferring resistance to Soybean mosaic virus and Bean common mosaic virus in the soybean cultivar Raiden
In the soybean cultivar Raiden, both a SMV-resistance gene and a BCMV-resistance gene were fine-mapped to a common region within the Rsv1 complex locus on chromosome 13, in which two CC-NBS-LRR resistance genes (
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Article
Open AccessThe lncRNA Neat1 promotes activation of inflammasomes in macrophages
The inflammasome has an essential function in innate immune, responding to a wide variety of stimuli. Here we show that the lncRNA Neat1 promotes the activation of several inflammasomes. Neat1 associates with the...
