901 Result(s)
-
Article
A novel adaptive meshless method for solving the nonlinear time fractional telegraph equations on arbitrary domains
A novel adaptive meshless numerical method for tackling with the two-dimensional time fractional telegraph equations on arbitrary domains based on partitioning domains is presented in this paper. The proposed ...
-
Article
Open AccessDual-targeted delivery of temozolomide by multi-responsive nanoplatform via tumor microenvironment modulation for overcoming drug resistance to treat glioblastoma
Glioblastoma (GBM) is the most aggressive primary brain tumor with low survival rate. Currently, temozolomide (TMZ) is the first-line drug for GBM treatment of which efficacy is unfortunately hindered by short...
-
Article
Norepinephrine–Astrocyte Signaling Regulates Cortical State Homeostasis
-
Article
Raising New Hope for Controlling Seizures in Focal Cortical Dysplasia with Gene Therapy
-
Article
Microstructure and Mechanical Properties of Static Shoulder Friction Stir Welding AA3003-H14
Aluminum alloy is one of the important materials in the field of automotive lightweight research; in order to meet the current demand for welding process of new energy power battery shell, this paper adopts st...
-
Article
PINK1 is involved in determining the cellular autophagic hierarchy
-
Article
Visualizing ICP “Dose” of neurological critical care patients
-
Article
Approximation Algorithms for Multiprocessor Scheduling with Testing to Minimize the Total Job Completion Time
In offline scheduling models, jobs are given with their exact processing times. In their online counterparts, jobs arrive in sequence together with their processing times and the scheduler makes irrevocable de...
-
Article
Rheum palmatum L. and Salvia miltiorrhiza Bge. Alleviates Acute Pancreatitis by Regulating Th17 Cell Differentiation: An Integrated Network Pharmacology Analysis, Molecular Dynamics Simulation and Experimental Validation
To identify the core targets of Rheum palmatum L. and Salvia miltiorrhiza Bge., (Dahuang-Danshen, DH-DS) and the mechanism underlying its therapeutic efficacy in acute pancreatitis (AP) using a network pharmacolo...
-
Article
Open AccessCorrection to: VEIN STEP: A Prospective, Observational, International Study to Assess Effectiveness of Conservative Treatments in Chronic Venous Disease
-
Article
A combination of QTL map** and genome-wide association study revealed the key gene for husk number in maize
Two key genes Zm00001d021232 and Zm00001d048138 were identified by QTL map** and GWAS. Additionally, they were verified to be significantly associated with maize husk number (HN) using gene-based association st...
-
Article
Novel Mechanism, Drug Target and Therapy in Epilepsy
-
Article
Surface evolution and subsurface damage mechanism in fixed abrasive lap** of Silicon carbide
Fixed abrasive lap** (FAL) is considered a promising technology in ultra-precision manufacturing of various hard and brittle materials due to its advantages, e.g., high finishing efficiency and eco-friendly....
-
Article
Sodium intake: a double-edged sword wielded by the brain
-
Article
Open AccessIdentifying influential nodes based on the disassortativity and community structure of complex network
The complex networks exhibit significant heterogeneity in node connections, resulting in a few nodes playing critical roles in various scenarios, including decision-making, disease control, and population immu...
-
Article
Open AccessMultilevel design and construction in nanomembrane rolling for three-dimensional angle-sensitive photodetection
Releasing pre-strained two-dimensional nanomembranes to assemble on-chip three-dimensional devices is crucial for upcoming advanced electronic and optoelectronic applications. However, the release process is a...
-
Article
Dissecting the networks underlying diverse brain disorders after prenatal glucocorticoid overexposure
New human life begins in the uterus in a period of both extreme plasticity and sensitivity to environmental disturbances. The fetal stage is also a vital period for central nervous system development, with exp...
-
Article
Functional Changes in Astrocytes Lead to Cognitive Deficits After Social Deprivation
-
Article
Open AccessImmune cells: potential carriers or agents for drug delivery to the central nervous system
Drug delivery systems (DDS) have recently emerged as a promising approach for the unique advantages of drug protection and targeted delivery. However, the access of nanoparticles/drugs to the central nervous s...
-
Article
Open AccessTransurethral surgical treatment for benign prostatic hyperplasia with detrusor underactivity: a systematic review and meta-analysis
The efficacy of surgical treatment for benign prostatic hyperplasia (BPH) patients with detrusor underactivity (DU) remains controversial.
