-
Article
Norepinephrine–Astrocyte Signaling Regulates Cortical State Homeostasis
-
Article
Functional Changes in Astrocytes Lead to Cognitive Deficits After Social Deprivation
-
Article
Open AccessExtend the benchmarking indel set by manual review using the individual cell line sequencing data from the Sequencing Quality Control 2 (SEQC2) project
Accurate indel calling plays an important role in precision medicine. A benchmarking indel set is essential for thoroughly evaluating the indel calling performance of bioinformatics pipelines. A reference samp...
-
Article
MeV astrophysical spectroscopic surveyor (MASS): a compton telescope mission concept
We propose a future mission concept, the MeV Astrophysical Spectroscopic Surveyor (MASS), which is a large area Compton telescope using 3D position sensitive cadmium zinc telluride (CZT) detectors optimized fo...
-
Article
Open AccessA Randomized Open-Label Study of Relugolix Alone or Relugolix Combination Therapy in Premenopausal Women
Relugolix is a gonadotropin-releasing hormone receptor antagonist. Relugolix 40-mg monotherapy is associated with vasomotor symptoms and long-term bone mineral density loss due to hypoestrogenism. This study a...
-
Article
Open AccessInterleukin-37 is involved in the immunopathogenesis of infectious mononucleosis
Multiple immunopathological responses to viruses are observed in infectious mononucleosis (IM), a manifestation of primary infection with Epstein-Barr virus (EBV). Protective effects of the negative immunoregu...
-
Article
Open AccessPhysics-informed machine-learning model of temperature evolution under solid phase processes
We model temperature dynamics during Shear Assisted Proccess Extrusion (ShAPE), a solid phase process that plasticizes feedstock with a rotating tool and subsequently extrudes it into a consolidated tube, rod,...
-
Chapter and Conference Paper
K-Means Based Multi-dimensional Charging Behavior Profiling Technique
With the full-scale construction of electric vehicle charging facilities, the back-end management data of charging users have been seen in the beginning. To this end, this paper performs data cleaning and stan...
-
Chapter and Conference Paper
Parameterized Doppler Adaptive Correction for Wayside Acoustic Array Signal
Trackside acoustic detection system (TADS) has been widely applied to monitor the status of bearings based on acoustic array signal. Whereas, the sound source movement results in the collected signal being dis...
-
Article
A prototype segmented planar high purity germanium detector using wraparound lithium diffusion electrode and amorphous germanium blocking contact
Segmented high purity germanium (HPGe) detectors have been used in many experiments to measure the position and energy deposition of gamma ray interactions. Significant efforts have been made to optimize the d...
-
Article
Open AccessActivated astrocytes attenuate neocortical seizures in rodent models through driving Na+-K+-ATPase
Epileptic seizures are widely regarded to occur as a result of the excitation-inhibition imbalance from a neuro-centric view. Although astrocyte-neuron interactions are increasingly recognized in seizure, elem...
-
Article
Open AccessCarotid artery corrected flow time and respiratory variations of peak blood flow velocity for prediction of hypotension after induction of general anesthesia in elderly patients
Postinduction hypotension is closely related to postoperative complications. Elderly patients with compromised cardiovascular compensatory reserve are more susceptible to hypotension after induction of general...
-
Article
Open AccessDorzagliatin add-on therapy to metformin in patients with type 2 diabetes: a randomized, double-blind, placebo-controlled phase 3 trial
Metformin, the first-line therapy for type 2 diabetes (T2D), decreases hepatic glucose production and reduces fasting plasma glucose levels. Dorzagliatin, a dual-acting orally bioavailable glucokinase activato...
-
Article
Higenamine mitigates interleukin-1β-induced human nucleus pulposus cell apoptosis by ROS-mediated PI3K/Akt signaling
Intervertebral disc degeneration (IDD) is a natural problem linked to the inflammation. Higenamine exerts multiple pharmacological properties in inflammation-related disorders. Our study aimed to explore the f...
-
Article
Physiologically Based Pharmacokinetic Models Are Effective Support for Pediatric Drug Development
Pediatric drug development faces many difficulties. Traditionally, pediatric drug doses are simply calculated linearly based on the body weight, age, and body surface area of adults. Due to the ontogeny of chi...
-
Article
First experimental constraints on WIMP couplings in the effective field theory framework from CDEX
We present weakly interacting massive particles (WIMPs) search results performed using two approaches of effective field theory from the China Dark Matter Experiment (CDEX), based on the data from both CDEX-1B...
-
Article
Open AccessDirect observation of nanoscale dynamics of ferroelectric degradation
Failure of polarization reversal, i.e., ferroelectric degradation, induced by cyclic electric loadings in ferroelectric materials, has been a long-standing challenge that negatively impacts the application of ...
-
Article
Adsorption of uranyl ion with polymer spheres modified by diamide
The extraction and recovery of uranium from low-concentration uranium-bearing liquids has practical and environmental value. The most efficient and economical method is adsorption. In this study, two novel ads...
-
Article
Open AccessElectroacupuncture pretreatment alleviates myocardial injury through regulating mitochondrial function
Electroacupuncture is well known for its advantageous neuroanalgesic and therapeutic effects on myocardial ischemia–reperfusion injury. The purpose of the present research was to verify whether electroacupunct...
-
Article
“Sintering” Models and In-Situ Experiments: Data Assimilation for Microstructure Prediction in SLS Additive Manufacturing of Nylon Components
Selective laser sintering methods are workhorses for additively manufacturing polymer-based components. The ease of rapid prototy** also means it is easy to produce illicit components. It is necessary to hav...
