693 Result(s)
within
Rui-** **ao
Life Sciences
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Article
Structure and assembly of the α-carboxysome in the marine cyanobacterium Prochlorococcus
Carboxysomes are bacterial microcompartments that encapsulate the enzymes RuBisCO and carbonic anhydrase in a proteinaceous shell to enhance the efficiency of photosynthetic carbon fixation. The self-assembly ...
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Open AccessActivation of GPR81 by lactate drives tumour-induced cachexia
Cachexia affects 50–80% of patients with cancer and accounts for 20% of cancer-related death, but the underlying mechanism driving cachexia remains elusive. Here we show that circulating lactate levels positiv...
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Dietary Iron Overload Triggers Hepatic Metabolic Disorders and Inflammation in Laying Hen
Iron, an essential trace element, is involved in various physiological processes; however, consumption of excessive iron possesses detrimental effects. In practical feed production, the iron content added to f...
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Open AccessArnicolide D induces endoplasmic reticulum stress-mediated oncosis via ATF4 and CHOP in hepatocellular carcinoma cells
Endoplasmic reticulum (ER) stress can trigger various cell death mechanisms beyond apoptosis, providing promise in cancer treatment. Oncosis, characterized by cellular swelling and increased membrane permeabil...
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The correct name for Gentiana albomarginata (Gentianaceae: Gentianeae)
Gentiana albomarginata C.Marquand was proposed as a replacement name for G. albescens (Franch.) Franch. ex Kusn., which was long considered as a later homonym of G. albescens Favre. However, G. albescens Favre w...
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Effects of low-temperature stress on serum biochemical indicators, intestinal microbiome, and transcriptome of juvenile golden pompano (Trachinotus ovatus)
Low temperatures pose a critical challenge to aquaculture operations, as they can significantly affect fish health and overall productivity. The study investigated the impact of low-temperature stress on juven...
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Open AccessRepositioning baloxavir marboxil as VISTA agonist that ameliorates experimental asthma
V-type immunoglobulin domain–containing suppressor of T-cell activation (VISTA), a novel negative checkpoint regulator, plays an essential role in allergic pulmonary inflammation in mice. Treatment with a VIST...
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Article
The lncRNA20718-miR6022-RLPs module regulates tomato resistance to Phytophthora infestans
Sl-lncRNA20718 acts as an eTM of Sl-miR6022 regulating its expression thereby affecting SlRLP6/10 expression. SlRLP6/10 regulate PRs expression, ROS accumulation, and JA/ET content thereby affecting tomato res...
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Article
Open AccessIL-8 activates fibroblasts to promote the invasion of HNSCC cells via STAT3-MMP1
Matrix metalloproteinase-1 (MMP1) has an aberrant expression relevant to various behaviors of cancers. As dominant components of the tumor stroma, fibroblasts constitute an important source of Matrix metallopr...
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LncRNA LY6E-DT and its encoded metastatic-related protein play oncogenic roles via different pathways and promote breast cancer progression
Abnormal long noncoding RNA (lncRNA) expression plays an important role in tumor invasion and metastasis. Here, we show that lncRNA LY6E divergent transcript (LY6E-DT) levels are increased in breast cancer (BC...
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Ecological filtering shapes the impacts of agricultural deforestation on biodiversity
The biodiversity impacts of agricultural deforestation vary widely across regions. Previous efforts to explain this variation have focused exclusively on the landscape features and management regimes of agricu...
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Growth characteristics and biomass model of Cupressus gigantea sapling
The growth characteristics and biomass model of Cupressus gigantea (34a). The biomass of each part of the tree was ranked in order of size: trunk > main branches > leaves > lateral branches > roots > fruits, w...
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Article
Artemisia argyi H. Lév. & Vaniot: a comprehensive review on traditional uses, phytochemistry, and pharmacological activities
Artemisia argyi, a perennial herb of the genus Artemisia, is recorded as medicine for the treatment of various diseases, such as metrorrhagia, menorrhagia, irregular menstruation, hemorrhage, dysmenorrhea, eczema...
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Open AccessTP53 to mediate immune escape in tumor microenvironment: an overview of the research progress
Increasing evidence suggests that key cancer-causing driver genes continue to exert a sustained influence on the tumor microenvironment (TME), highlighting the importance of immunotherapeutic targeting of gene...
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Open AccessNMDARs activation regulates endothelial ferroptosis via the PP2A-AMPK-HMGB1 axis
N-methyl-D-aspartate receptors (NMDARs) are ligand-gated, voltage-dependent channels of the ionotropic glutamate receptor family. The present study explored whether NMDAR activation induced ferroptosis in vasc...
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Diversified crop** systems with complementary root growth strategies improve crop adaptation to and remediation of hostile soils
Hostile soil conditions have a global impact on crop production. While root traits of individual plant species adapted to specific hostile soils are well studied, a comprehensive synthesis of how to use divers...
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Shifted plant composition predominantly controls nitrogen addition effect on community-level leaf nutrient resorption in a boreal peatland
Leaf nutrient resorption process is an indispensable aspect of plant nutrient utilization strategies in boreal peatlands. However, how nitrogen (N) enrichment alters leaf nutrient resorption is unclear at both...
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Open AccessTargeting the E2F1/Rb/HDAC1 axis with the small molecule HR488B effectively inhibits colorectal cancer growth
Colorectal cancer (CRC), the third most common cancer worldwide, remains highly lethal as the disease only becomes symptomatic at an advanced stage. Growing evidence suggests that histone deacetylases (HDACs),...
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Article
Pyroptosis in neurodegenerative diseases: from bench to bedside
The central nervous system regulates all aspects of physiology to some extent. Neurodegenerative diseases (NDDs) lead to the progressive loss and dysfunction of neurons, which are particularly evident in Alzhe...
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Comparison of demineralized bone matrix with different cycling crushing times in posterolateral fusion model of athymic rats
Decalcified bone matrix (DBM) is a widely used alternative material for bone transplantation. In the DBM production process, an effective particle size and the highest utilization rate of raw materials can be ...
