37 Result(s)
within
Hui-** Hsu
Biomedicine, general
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Article
Open AccessIdentification of rare variants for hypertension with incorporation of linkage information
We conducted linkage analysis using the genome-wide association study data on chromosome 3, and then assessed association between hypertension and rare variants of genes located in the regions showing evidence...
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Article
Zebrafish rgs4 is essential for motility and axonogenesis mediated by Akt signaling
The schizophrenia susceptibility gene, Rgs4, is one of the most intensively studied regulators of G-protein signaling members, well known to be fundamental in regulating neurotransmission. However, little is know...
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Article
Open AccessHerpes zoster is associated with an increased risk of subsequent lymphoid malignancies - A nationwide population-based matched-control study in Taiwan
Infectious agents have been shown to contribute to the development of lymphoid malignancies. The different distribution of lymphoid malignancies in Asian and Western populations suggests possibly different eti...
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Article
Glycated hemoglobin A1c is superior to fasting plasma glucose as an independent risk factor for colorectal neoplasia
To investigate which glycemic index is more strongly associated with colorectal neoplasia.
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Article
Renal Cell Carcinoma with t(X;17)(p11.2;q25) in a 5-year-old Taiwanese Boy. A Case Report and Review of the Literature
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Article
Open AccessCorrelation of microarray-based breast cancer molecular subtypes and clinical outcomes: implications for treatment optimization
Optimizing treatment through microarray-based molecular subty** is a promising method to address the problem of heterogeneity in breast cancer; however, current application is restricted to prediction of dis...
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Open AccessRetrospective comparison between a regular and a split-dose protocol of 5-fluorouracil, cisplatin, and mitoxantrone for the treatment of far advanced hepatocellular carcinoma
In patients with advanced hepatocellular carcinoma (HCC), combination chemotherapy using 5- fluorouracil, cisplatin, and mitoxantrone (FMP) could achieve a response rate > 20%, but the beneficial effect was co...
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Article
Action potential bursts in central snail neurons elicited by paeonol: roles of ionic currents
To investigate the effects of 2′-hydroxy-4′-methoxyacetophenone (paeonol) on the electrophysiological behavior of a central neuron (right parietal 4; RP4) of the giant African snail (Achatina fulica Ferussac).
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Article
Overexpression of ornithine decarboxylase suppresses thapsigargin-induced apoptosis
Ornithine decarboxylase (ODC), the key enzyme of polyamine biosynthesis, has paradoxical roles in apoptosis. Our published papers show overexpression of ODC prevents the apoptosis induced by many cytotoxic dru...
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Article
Open AccessEnterovirus type 71 2A protease functions as a transcriptional activator in yeast
Enterovirus type 71 (EV71) 2A protease exhibited strong transcriptional activity in yeast cells. The transcriptional activity of 2A protease was independent of its protease activity. EV71 2A protease retained ...
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Article
Open AccessAssessment of gene-covariate interactions by incorporating covariates into association map**
The HLA region is considered to be the main genetic risk factor for rheumatoid arthritis. Previous research demonstrated that HLA-DRB1 alleles encoding the shared epitope are specific for disease that is characte...
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Article
Open AccessIncreased ATP generation in the host cell is required for efficient vaccinia virus production
To search for cellular genes up-regulated by vaccinia virus (VV) infection, differential display-reverse transcription-polymerase chain reaction (ddRT-PCR) assays were used to examine the expression of mRNAs f...
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Article
Interleukin 17–producing T helper cells and interleukin 17 orchestrate autoreactive germinal center development in autoimmune BXD2 mice
Interleukin 17 (IL-17) is a cytokine associated with inflammation, autoimmunity and defense against some bacteria. Here we show that IL-17 can promote autoimmune disease through a mechanism distinct from its p...
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Article
Open AccessIncorporating quantitative variables into linkage analysis using affected sib pairs
Rheumatoid arthritis is a complex disease in which environmental factors interact with genetic factors that influence susceptibility. Incorporating information about related quantitative traits or environmenta...
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Article
Open AccessAssessing genotype × environment interaction in linkage map** using affected sib pairs
Rheumatoid arthritis (RA) is a complex disease that involves both environmental and genetic factors. Elucidation of the basic etiologic factors involved in RA is essential for preventing and treating this dise...
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Article
Establishment of red fluorescent protein-tagged HeLa tumor metastasis models: Determination of DsRed2 insertion effects and comparison of metastatic patterns after subcutaneous, intraperitoneal, or intravenous injection
Metastasis is the leading cause of death in patients with cervical cancer. In this report, we establish novel fluorescent HeLa tumor metastasis models to determine whether HeLa transfected with the enhanced re...
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Article
Inhibitory effect of phorbol ester on carbachol-induced signal transduction in cultured canine tracheal smooth muscle cells
Regulation of the increases in inositol 1,4,5-trisphosphate (IP3) production and intracellular Ca2+ concentration ([Ca2+]i) by activation of protein kinase C (PKC) was investigated in cultured canine tracheal smo...
