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Article
Impaired gut barrier integrity and reduced colonic expression of free fatty acid receptors in patients with Parkinson’s disease
Altered gut metabolites, especially short-chain fatty acids (SCFAs), in feces and plasma are observed in patients with Parkinson’s disease (PD).
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Article
Open AccessCancer screening programs in South-east Asia and Western Pacific
The burden of cancer can be altered by screening. The field of cancer screening is constantly evolving; from the initiation of program for new cancer types as well as exploring innovative screening strategies ...
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Article
Open AccessTwnbiome: a public database of the healthy Taiwanese gut microbiome
With new advances in next generation sequencing (NGS) technology at reduced costs, research on bacterial genomes in the environment has become affordable. Compared to traditional methods, NGS provides high-thr...
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Article
Open AccessAssessing overdiagnosis of fecal immunological test screening for colorectal cancer with a digital twin approach
Evaluating the magnitude of overdiagnosis associated with stool-based service screening for colorectal cancer (CRC) beyond a randomized controlled trial is often intractable and understudied. We aim to estimat...
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Article
Positive and negative impact of anti-reflux mucosal intervention on gastroesophageal reflux disease
Anti-reflux mucosal intervention (ARMI), including anti-reflux mucosectomy (ARMS) and anti-reflux mucosal ablation (ARMA), is a promising endoscopic treatment for gastroesophageal reflux disease (GERD). Few st...
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Article
Open AccessQueue hurdle Coxian phase-type model for two-stage process of population-based cancer screening
The quality assurance of two-stage population-based cancer screening program is determined by arrival rate (attending screening), positive rate (determined by the criteria of screening test), the compliance an...
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Article
Open AccessBrand interchangeability of pepsinogen tests in the real-world setting after eradication of Helicobacter pylori: a community-based study
Serum pepsinogen (PG) is recommended as a screening test for premalignant gastric lesions. However, real-world evidence demonstrating its applicability and equivalence between different test brands is limited.
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Article
Optimal surveillance interval after piecemeal endoscopic mucosal resection for large colorectal neoplasia: a multicenter randomized controlled trial
Colorectal neoplastic lesions (≥ 20 mm) are commonly treated via piecemeal endoscopic mucosal resection (p-EMR) but have a high rate of local recurrence. We aimed to clarify the optimal surveillance interval a...
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Article
Open AccessOverbooking for physical examination considering late cancellation and set-resource relationship
Late cancellations of physical examination has severe impact on the operations of a physical examination center since it is often too late to fill vacancy. A booking control policy that considers overbooking i...
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Chapter
Endoscopic Mucosal Resection: EMR for the Colon
Although endoscopic submucosal dissection (ESD) had become a mainstay of the endoluminal treatment of upper gastrointestinal cancers, endoscopic mucosal resection (EMR) still plays an important role for the tr...
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Chapter
Diagnosis of Early Colorectal Carcinoma: Endoscopic Diagnosis and Classification
Accurate endoscopic diagnosis of early colorectal cancer (CRC) is of utmost importance, as it can guide treatment in terms of endoscopic resection or surgery. Compared with surgery, endoluminal treatment can s...
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Chapter
Noninvasive Screening Test
Noninvasive colorectal cancer (CRC) screening test enables selection of subjects at risk of significant neoplasm (cancer or advanced adenoma) from a large target screening population. It may, therefore, reduce...
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Chapter
Quality Assurance in Colorectal Cancer Screening Program
In an organized screening, quality assurance by setting targets to be met and continuous monitoring of key indicators using the relevant data collected within a program is its major difference from opportunist...
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Article
The Rise of Colorectal Cancer in Asia: Epidemiology, Screening, and Management
Colorectal cancer (CRC) remains the third most commonly diagnosed cancer globally, and its incidence and mortality rates have been on the rise in Asia. In this paper, we summarize the recent trends and screeni...
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Article
Open AccessQuantile-based fecal hemoglobin concentration for assessing colorectal neoplasms with 1,263,717 Taiwanese screenees
Although fecal hemoglobin concentration (f-Hb) was highly associated with the risk of colorectal neoplasms, current studies on this subject are hampered by skewedness of the data and the ordinal property of f-...
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Article
Open AccessComparison of cold and hot snaring polypectomy for small colorectal polyps: study protocol for a randomized controlled trial
Colorectal cancer remains a considerable challenge in healthcare nowadays. Most patients’ disease develops via the adenoma–carcinoma sequence; colonoscopy with polypectomy effectively reduces both mortality an...
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Article
Colorectal Cancer Screening in Asia
Colorectal cancer (CRC) is increasing in Asia, especially in regions with higher levels of economic development. Several Asian countries have launched population CRC screening programs to combat this devastati...
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Article
Prospective evaluation of endoscopic criteria characteristic of sessile serrated adenomas/polyps
Differentiating sessile serrated adenoma/polyp (SSA/P) from hyperplastic polyp (HP) is clinically important in determining the necessity of endoscopic resection or recommending appropriate surveillance. There ...
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Article
Open AccessMutational profiles of different macroscopic subtypes of colorectal adenoma reveal distinct pathogenetic roles for KRAS, BRAF and PIK3CA
Investigations of genetic alterations and correlations with histology or morphology could provide further insights into colorectal carcinogenesis. Nevertheless, such genetic changes were less investigated in a...
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Article
Glycated hemoglobin A1c is superior to fasting plasma glucose as an independent risk factor for colorectal neoplasia
To investigate which glycemic index is more strongly associated with colorectal neoplasia.
