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  1. Article

    Open Access

    Imbalances in the disposition of estrogen and naphthalene in breast cancer patients: a potential biomarker of breast cancer risk

    Elevation of naphthoquinones and estrogen quinones, which are reactive metabolites of naphthalene and estrogen, is thought to be an important indicator of naphthalene- and estrogen-induced carcinogenesis. We c...

    Dar-Ren Chen, Wei-Chung Hsieh, Yi-Lun Liao, Kuo-Juei Lin, Yu-Fen Wang in Scientific Reports (2020)

  2. No Access

    Article

    Genetic polymorphisms in APE1 Asp148Glu(rs3136820) as a modifier of the background levels of abasic sites in human leukocytes derived from breast cancer patients and controls

    Apurinic/apyrimidinic (abasic/AP) sites are among the most common endogenous DNA lesions. AP sites, if not repaired, could result in genomic instability as well as chromosome aberrations. Information regarding...

    Wei-Chung Hsieh, Che Lin, Dar-Ren Chen, Wen-Fa Yu, Guan-Jie Chen in Breast Cancer (2017)

  3. No Access

    Article

    Overexpression of ornithine decarboxylase suppresses thapsigargin-induced apoptosis

    Ornithine decarboxylase (ODC), the key enzyme of polyamine biosynthesis, has paradoxical roles in apoptosis. Our published papers show overexpression of ODC prevents the apoptosis induced by many cytotoxic dru...

    Wei-Chung Hsieh, Pei-Chen Hsu, Ya-Fan Liao, Shu-Ting Young in Molecules and Cells (2010)