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Chapter
Statistical Evaluation of Markers and Risk Tools for Prostate Cancer Classification and Prediction
Adopting novel biomarkers for use in prostate cancer screening requires rigorous scientific evaluation. The predictive accuracy of the markers must be quantified and compared with other potential markers. In t...
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Chapter
The Performance Characteristics of Prostate-Specific Antigen for Prostate Cancer Screening
When considering the application of a screening test for any disease, it is extremely important to understand how the performance characteristics of a test will affect its usefulness to a patient as well as to...
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Article
Sequestosome 1 (SQSTM1) Mutations in Paget’s Disease of Bone from the United States
Paget’s disease of bone (PDB) is a localized bone disease characterized by excessive bone resorption due to overactive osteoclasts. Seven genetic loci (PDB1-PDB7) have been reported for late-onset PDB. PDB3 is...
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Article
Open AccessImpact of cryopreservation on tetramer, cytokine flow cytometry, and ELISPOT
Cryopreservation of PBMC and/or overnight ship** of samples are required for many clinical trials, despite their potentially adverse effects upon immune monitoring assays such as MHC-peptide tetramer stainin...
