9 Result(s)
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Teresa L. Johnson-Pais
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Article
Prospective comparison of restriction spectrum imaging and non-invasive biomarkers to predict upgrading on active surveillance prostate biopsy
Protocol-based active surveillance (AS) biopsies have led to poor compliance. To move to risk-based protocols, more accurate imaging biomarkers are needed to predict upgrading on AS prostate biopsy. We compare...
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Article
Open AccessEffects of vortioxetine on hippocampal-related cognitive impairment induced in rats by androgen deprivation as a model of prostate cancer treatment
Advances in prostate cancer treatment have significantly improved survival, but quality of life for survivors remains an under-studied area of research. Androgen deprivation therapy (ADT) is a foundational tre...
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Article
Open AccessComparison of rectal swab, glove tip, and participant-collected stool techniques for gut microbiome sampling
Studies of the gut microbiome are becoming increasingly important. Such studies require stool collections that can be processed or frozen in a timely manner so as not to alter the microbial content. Due to the...
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Article
IL-1 promotes α-epithelial Sodium Channel (α-ENaC) expression in murine lung epithelial cells: involvement of NF-κB
Intra-amniotic exposure to proinflammatory cytokines such as interleukin-1 (IL-1) correlates with a decreased incidence of respiratory distress syndrome (RDS) in infants following premature birth. At birth, in...
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Article
Vortioxetine reverses medial prefrontal cortex-mediated cognitive deficits in male rats induced by castration as a model of androgen deprivation therapy for prostate cancer
Androgen deprivation therapy (ADT) is an effective treatment for prostate cancer, but induces profound cognitive impairment. Little research has addressed mechanisms underlying these deficits or potential trea...
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Article
Open AccessXBSeq2: a fast and accurate quantification of differential expression and differential polyadenylation
RNA sequencing (RNA-seq) is a high throughput technology that profiles gene expression in a genome-wide manner. RNA-seq has been mainly used for testing differential expression (DE) of transcripts between two ...
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Biomarkers for Prostate Cancer Detection: Family-Based Linkage Analysis and Case–Control Association Studies
For decades, it has been well-recognized that genetics plays a critical role in the development of prostate cancer. Numerous epidemiological and molecular biological studies have shown evidence for a significa...
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Article
Sequestosome 1 (SQSTM1) Mutations in Paget’s Disease of Bone from the United States
Paget’s disease of bone (PDB) is a localized bone disease characterized by excessive bone resorption due to overactive osteoclasts. Seven genetic loci (PDB1-PDB7) have been reported for late-onset PDB. PDB3 is...
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Article
Extinction of liver/bone/kidney alkaline phosphatase in osteosarcoma hybrid cells
We have constructed a series of interspecific somatic cell hybrids between the human osteoblast-like osteosarcoma, TE85, and a mouse fibrosarcoma, La−t−. In these whole-cell hybrids, we observed a 10-fold reducti...
