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Ipilimumab with or without nivolumab in PD-1 or PD-L1 blockade refractory metastatic melanoma: a randomized phase 2 trial
In this randomized phase 2 trial, blockade of cytotoxic T-lymphocyte protein 4 (CTLA-4) with continuation of programmed death protein 1 (PD-1) blockade in patients with metastatic melanoma who had received fro...
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Arrhythmogenic cardiomyopathy and differential diagnosis with physiological right ventricular remodelling in athletes using cardiovascular magnetic resonance
To describe the overlap between structural abnormalities typical of arrhythmogenic right ventricular cardiomyopathy (ARVC) and physiological right ventricular adaptation to exercise and differentiate between p...
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Open AccessEffect of remote ischaemic conditioning on infarct size and remodelling in ST-segment elevation myocardial infarction patients: the CONDI-2/ERIC-PPCI CMR substudy
The effect of limb remote ischaemic conditioning (RIC) on myocardial infarct (MI) size and left ventricular ejection fraction (LVEF) was investigated in a pre-planned cardiovascular magnetic resonance (CMR) s...
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Open AccessA deep learning methodology for the automated detection of end-diastolic frames in intravascular ultrasound images
Coronary luminal dimensions change during the cardiac cycle. However, contemporary volumetric intravascular ultrasound (IVUS) analysis is performed in non-gated images as existing methods to acquire gated or t...
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Continuous versus intermittent BRAF and MEK inhibition in patients with BRAF-mutated melanoma: a randomized phase 2 trial
Preclinical modeling suggests that intermittent BRAF inhibitor therapy may delay acquired resistance when blocking oncogenic BRAFV600 in melanoma1,2. We conducted S1320, a randomized, open-label, phase 2 clinical...
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Open AccessA randomised controlled trial evaluating arrhythmia burden, risk of sudden cardiac death and stroke in patients with Fabry disease: the role of implantable loop recorders (RaILRoAD) compared with current standard practice
Fabry disease (FD) is a genetic disorder caused by a deficiency in the enzyme alpha-galactosidase A, leading to an accumulation of glycosphingolipids in tissues across the body. Cardiac disease is the leading ...
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Open Access2.6 Feasibility of Aortic Wave Intensity Analysis from Sequentially Acquired Cardiac Mri and Non-Invasive Central Blood Pressure
Wave intensity analysis (WIA) in the aorta offers important clinical and mechanistic insights but is difficult non-invasively. We performed WIA by combining high temporal resolution cardiovascular magnetic res...
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Open AccessP187: in Severe Aortic Stenosis, Decreased Systemic Vascular Resistance is associated with A Larger, Thicker Walled Ventricle Except for the Septum
The ventricle in aortic stenosis (AS) is influenced by both valvular and vascular factors. The importance of afterload on left ventricular (LV) remodeling is not completely understood. Traditional imaging tech...
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Open Access31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part two
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Open AccessCurrent provision for MRI scanning of patients with cardiac implantable electronic devices - a national survey of hospitals in England
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Open AccessAutomatic left ventricular analysis with Inline VF performs well compared to manual analysis: results from Barts Cardiovascular Registry
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Open AccessNative T1 map** versus CMR Feature Tracking (FT) derived strain analysis for the assessment of cardiac disease manifestation in Anderson Fabry
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Open AccessChronic iron deposit and left ventricular remodeling in reperfused STEMI patients
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Open AccessUltrafast CMR to deliver high volume screening of an at risk thalassemia population in the develo** world: preliminary results from the TIC-TOC study (Thailand and UK international collaboration in thalassaemia using an optimised ultrafast CMR protocol)
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Open AccessHematocrit, iron and HDL-cholesterol explain 90% of variation in native blood T1
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Open AccessLeft ventricular remodeling after reperfused acute myocardial infarction: insights from automated ECV map**
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Open AccessThe Right ventricle and cardiac surgery - more resilient than thought: multiparametric quantification shows altered rather than reduced function
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Open AccessQuantifying right ventricular diffuse fibrosis in tetralogy of Fallot - a novel customised approach for the challenges of the right ventricle
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Open AccessThe association of left atrial volume with age, ethnicity and cardiovascular risk factors in men and women: the Multi-Ethnic Study of Atherosclerosis (MESA)
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Open AccessCMR findings in high endurance veteran athletes - a 247 subject study
