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Article
Open AccessBidirectional modulation of TCA cycle metabolites and anaplerosis by metformin and its combination with SGLT2i
Metformin and sodium-glucose-cotransporter-2 inhibitors (SGLT2i) are cornerstone therapies for managing hyperglycemia in diabetes. However, their detailed impacts on metabolic processes, particularly within th...
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Article
Open AccessPredicting clinically significant prostate cancer following suspicious mpMRI: analyses from a high-volume center
mpMRI is routinely used to stratify the risk of clinically significant prostate cancer (csPCa) in men with elevated PSA values before biopsy. This study aimed to calculate a multivariable risk model incorporat...
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Article
Open AccessPrevalence and determinants of decision regret in long-term prostate cancer survivors following radical prostatectomy
Patients with localized prostate cancer (PC) are faced with a wide spectrum of therapeutic options at initial diagnosis. Following radical prostatectomy (RP), PC patients may experience regret regarding their ...
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Article
Open AccessAssociation between short-term exposure to air pollution and COVID-19 mortality in all German districts: the importance of confounders
The focus of many studies is to estimate the effect of risk factors on outcomes, yet results may be dependent on the choice of other risk factors or potential confounders to include in a statistical model. For...
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Article
Open AccessAccommodating heterogeneous missing data patterns for prostate cancer risk prediction
We compared six commonly used logistic regression methods for accommodating missing risk factor data from multiple heterogeneous cohorts, in which some cohorts do not collect some risk factors at all, and deve...
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Article
Open AccessLong-term and pathological outcomes of low- and intermediate-risk prostate cancer after radical prostatectomy: implications for active surveillance
The safety of active surveillance (AS) in favorable intermediate-risk (FIR) prostate cancer (PCa) remains uncertain. To provide guidance on clinical decision-making, we examined long-term and pathological outc...
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Article
Open AccessDiversity of cancer-related identities in long-term prostate cancer survivors after radical prostatectomy
Individuals affected by cancer need to integrate this experience into their personal biography as their life continues after primary therapy, leading to substantial changes in self-perception. This study ident...
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Article
Open AccessNo detrimental effect of a positive family history on postoperative upgrading and upstaging in men with low risk and favourable intermediate-risk prostate cancer: implications for active surveillance
To assess whether a first-degree family history or a fatal family history of prostate cancer (PCa) are associated with postoperative upgrading and upstaging among men with low risk and favourable intermediate-...
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Article
Open AccessMulti-cohort modeling strategies for scalable globally accessible prostate cancer risk tools
Online clinical risk prediction tools built on data from multiple cohorts are increasingly being utilized for contemporary doctor-patient decision-making and validation. This report outlines a comprehensive da...
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Article
Men with family history of prostate cancer have a higher risk of disease recurrence after radical prostatectomy
We aimed to determine if family history (FH) of prostate cancer (PC) influenced cancer control after radical prostatectomy (RP).
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Article
Open AccessA case control study of sarcosine as an early prostate cancer detection biomarker
Sarcosine has been investigated as a prostate cancer biomarker with mixed results concerning its predictive power. We performed a case–control evaluation of the predictive value of serum sarcosine for early de...
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Article
Daily growth of European beech (Fagus sylvatica L.) on moist sites is affected by short-term drought rather than ozone uptake
Daily stem growth was reduced by drought with high significance, but not affected by ozone uptake or drought–ozone interaction. Increasing air temperature showed capacity of compensating negati...
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Article
Association of tree and plot characteristics with microhabitat formation in European beech and Douglas-fir forests
Process-orientated, unmanaged forest remnants are not sufficient for halting the loss of forest biodiversity. Thus, integrated biodiversity-promoting management for forest inhabitants is needed. Microhabitats,...
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Article
Evaluating the Prostate Cancer Prevention Trial High Grade prostate cancer risk calculator in 10 international biopsy cohorts: results from the prostate biopsy collaborative group
To assess the applicability of the Prostate Cancer Prevention Trial High Grade (Gleason grade ≥ 7) Risk Calculator (PCPTHG) in ten international cohorts, representing a range of populations.
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Article
Prostate cancer incidence and survival in immigrants to Sweden
The large international variation in the incidence of prostate cancer (PC) is well known but the underlying reasons are not understood. We want to compare PC incidence and survival among immigrants to Sweden i...
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Article
Evaluating the PCPT risk calculator in ten international biopsy cohorts: results from the Prostate Biopsy Collaborative Group
To evaluate the discrimination, calibration, and net benefit performance of the Prostate Cancer Prevention Trial Risk Calculator (PCPTRC) across five European randomized study of screening for prostate cancer ...
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Article
Editorial for special issue on epidemiology and prevention of prostate cancer
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Article
Open AccessAssociation analysis of frost tolerance in rye using candidate genes and phenotypic data from controlled, semi-controlled, and field phenoty** platforms
Frost is an important abiotic stress that limits cereal production in the temperate zone. As the most frost tolerant small grain cereal, rye (Secale cereale L.) is an ideal cereal model for investigating the gene...
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Chapter
Pitfalls in Prostate Cancer Biomarker Evaluation Studies
Biomarker studies in prostate cancer research aim to discover new markers or novel uses of prostate-specific antigen (PSA) to complement or replace PSA as the existing standard for screening. These studies oft...
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Chapter
Development of the Prostate Cancer Prevention Trial Prostate Cancer Risk Calculator
The Prostate Cancer Prevention Trial (PCPT) Prostate Cancer Risk Calculator provides a single probability of prostate cancer and of high-grade disease (Gleason grade
