74 Result(s)

Chapter

Cytokine Cascades in HIV Infection

Since the recognition of human immunodeficiency virus type 1 (HIV-1) as the causative agent of the acquired immunodeficiency syndrome (AIDS), the search to unravel the viral and cellular factors controlling it...

Guido Poli, Anthony S. Fauci in Immunology of HIV Infection (1996)

Article

Interleukin-2 and human immunodeficiency virus infection: Pathogenic mechanisms and potential for immunologic enhancement

A hallmark of human immunodeficiency virus (HIV) infection is the progressive loss of CD4+ T lymphocytes; however, qualitative defects in immune responses occur prior to the precipitous drop CD4+ T cell number...

Audrey Kinter, Anthony S. Fauci in Immunologic Research (1996)

Article

Resistance to HIV–1 infection: It's in the genes

A genetic defect in the HIV-1 co-receptor provides resistance to infection.

Anthony S. Fauci in Nature Medicine (1996)

Article

Host factors and the pathogenesis of HIV-induced disease

The level of human immunodeficiency virus (HIV) replication in patients reflects a balance between stimulatory and inhibitory host factors (particularly endogenous cytokines). New information concerning the ce...

Anthony S. Fauci in Nature (1996)

Chapter

Virologic and immunologic events in primary HIV infection

It is thought that a significant percentage (50-70%) of human immunodeficiency virus (HIV)-infected individuals experience a clinical syndrome of variable severity during primary infection. The symptoms are no...

Guiseppe Pantaleo, Cecilia Graziosi… in Immunopathogenesis of HIV Infection (1997)

Chapter

Introduction: Recent advances in the pathogenesis of human immunodeficiency virus infection

During the last 5 years, major advances have been made in our understanding of the pathogenesis of human immunodeficiency virus (HIV) disease and in the development of new potent antiviral agents. With regard ...

Guiseppe Pantaleo, Anthony S. Fauci in Immunopathogenesis of HIV Infection (1997)

Chapter

Dendritic Cells Express and Use Multiple HIV Coreceptors

Dendritic cells (DC) are the first immunocompetent cells to encounter antigen at areas of inflammation in mucous membranes¹, which are the major sites where the initiation of HIV infection occurs. HIV enters a mu...

Drew Weissman, Andrea Rubbert… in Dendritic Cells in Fundamental and Clinica… (1997)

Chapter

Studies on lymphoid tissue from HIV-infected individuals: implications for the design of therapeutic strategies

Lymphoid tissue is a major reservoir of human immunodeficiency virus (HIV) infection in vivo. In addition, the lymphoid microenvironment provides a replicative advantage to the virus in that it provides a mili...

Oren J. Cohen, Giuseppe Pantaleo, Gordon K. Lam… in Immunopathogenesis of HIV Infection (1997)

Article

Inherited Resistance to HIV-1 Conferred by an Inactivating Mutation in CC Chemokine Receptor 5: Studies in Populations with Contrasting Clinical Phenotypes, Defined Racial Background, and Quantified Risk

CC chemokine receptor 5 (CCR5) is a cell entry cofactor for macrophage-tropic isolates of human immunodeficiency virus-1 (HIV-1). Recently, an inactive CCR5 allele (designated here as CCR5-2) was identified th...

Peter A. Zimmerman, Alicia Buckler-White, Ghalib Alkhatib… in Molecular Medicine (1997)

Article

Virologic and immunologic events in primary HIV infection

Guiseppe Pantaleo, Cecilia Graziosi… in Springer Seminars in Immunopathology (1997)

Article

Introduction: Recent advances in the pathogenesis of human immunodeficiency virus infection

Giuseppe Pantaleo, Anthony S. Fauci in Springer Seminars in Immunopathology (1997)

Article

Studies on lymphoid tissue from HIV-infected individuals: implications for the design of therapeutic strategies

Lymphoid tissue is a major reservoir of human immunodeficiency virus (HIV) infection in vivo. In addition, the lymphoid microenvironment provides a replicative advantage to the virus in that it provides a mili...

Oren J. Cohen, Giuseppe Pantaleo, Gordon K. Lam… in Springer Seminars in Immunopathology (1997)

Article

Macrophage-tropic HIV and SIV envelope proteins induce a signal through the CCR5 chemokine receptor

Human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) enter target cells by forming a complex between the viral envelope protein and two cell-surface membrane receptors: CD4 and a 7-span t...

Drew Weissman, Ronald L. Rabin, James Arthos, Andrea Rubbert, Mark Dybul… in Nature (1997)

Article

Evolutionary pattern of human immunodeficiency virus (HIV) replication and distribution in lymph nodes following primary infection: Implications for antiviral therapy

Evolutionary patterns of virus replication and distribution in lymphoid tissue during the early phases of HIV infection have not been delineated. Lymph node (LN) biopsies were excised from patients at differen...

Giuseppe Pantaleo, Oren J. Cohen, Timothy Schacker, Mauro Vaccarezza… in Nature Medicine (1998)

Article

Effect of interleukin-2 on the pool of latently infected, resting CD4⁺ T cells in HIV-1-infected patients receiving highly active anti-retroviral therapy

The size of the pool of resting CD4⁺ T cells containing replication-competent HIV in the blood of patients receiving intermittent interleukin (IL)-2 plus highly active anti-retroviral therapy (HAART) was signific...

Tae-Wook Chun, Delphine Engel, Stephanie B. Mizell, Claire W. Hallahan… in Nature Medicine (1999)

Article

Re-emergence of HIV after stop** therapy

A dormant reservoir of human immuno-deficiency virus (HIV) is established early on during primary infection¹ which consists of latently infected, resting CD4⁺ T cells carrying replication-competent HIV. This pool...

Tae-Wook Chun, Richard T. Davey Jr, Delphine Engel, H. Clifford Lane… in Nature (1999)

Article

Relationship between pre-existing viral reservoirs and the re-emergence of plasma viremia after discontinuation of highly active anti-retroviral therapy

We examined the pathogenic significance of the latent viral reservoir in the resting CD4⁺ T cell compartment of HIV-1-infected individuals as well as its involvement in the rebound of plasma viremia after discont...

Tae-Wook Chun, Richard T. Davey Jr., Mario Ostrowski, J. Shawn Justement… in Nature Medicine (2000)