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Article
Open AccessEffect of low vacuum medium temperature drying on reduction of residual stress and correction of warp of Japanese cedar timber
Cryptomeria japonica (Japanese cedar) in Japan plantations are aging, and the main supply of timber in the market is shifting from small- and medium-diameter to large-diameter logs. The effective utilization of t...
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Article
Open AccessThe HLA-DRB1*09:01-DQB1*03:03 haplotype is associated with the risk for late-onset Alzheimer’s disease in APOE \({{\varepsilon }}\) 4–negative Japanese adults
Late-onset Alzheimer’s disease (LOAD) is the most common cause of dementia among those older than 65 years. The onset of LOAD is influenced by neuroinflammation. The human leukocyte antigen (HLA) system is inv...
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Article
Open AccessClinical characteristics of geriatric patients with non-specific chronic low back pain
A comprehensive analysis of clinical information in patients with chronic low back pain (CLBP) was performed to clarify the clinical characteristics of geriatric LBP from the perspective of body composition, s...
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Article
Open AccessRole of collagen degradation pathway in sphingomyelin synthase 2-deficient mouse skin
Sphingomyelin synthase (SMS) is the only enzyme that synthesizes sphingomyelin from ceramide. The role of sphingomyelin synthase in epidermis is being understood, but there is no report on its role in the derm...
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Article
Open AccessEffects of once-yearly zoledronic acid on bone density and incident vertebral fractures in nonmetastatic castration-sensitive prostate cancer patients with osteoporosis
Androgen deprivation therapy (ADT) is the effective treating prostate cancer but is often accompanied by cancer treatment-induced bone loss (CTIBL), which impairs the patient’s quality of life. In patients wit...
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Article
Open AccessBeta-hydroxybutyrate, an endogenous NLRP3 inflammasome inhibitor, attenuates anxiety-related behavior in a rodent post-traumatic stress disorder model
Accumulating evidence suggests that elevated inflammation contributes to the pathophysiology of post-traumatic stress disorder (PTSD) and that anti-inflammatory drugs might be a new treatment strategy for PTSD...
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Article
Open AccessGrowth Factor Midkine Aggravates Pulmonary Arterial Hypertension via Surface Nucleolin
Pulmonary arterial hypertension (PAH) is a progressive fatal disease caused by pulmonary arterial remodeling. Midkine regulates cell proliferation and migration, and it is induced by hypoxia, but its roles in ...
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Article
Open AccessDeficiency of sphingomyelin synthase 1 but not sphingomyelin synthase 2 reduces bone formation due to impaired osteoblast differentiation
There are two isoforms of sphingomyelin synthase (SMS): SMS1 and SMS2. SMS1 is located in the Golgi apparatus only while SMS2 is located in both the plasma membrane and the Golgi apparatus. SMS1 and SMS2 act s...
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Article
Open AccessQuantitative evaluation of digital-image enhancement during heads-up surgery
Image-processing is an advantage of heads-up surgery and expected to facilitate ophthalmic surgeries. To evaluate image-processing quantitatively, we analyzed the surgical images of twenty eyes that underwent ...
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Article
Open AccessSoft and Robust Identification of Body Fluid Using Fourier Transform Infrared Spectroscopy and Chemometric Strategies for Forensic Analysis
Body fluid (BF) identification is a critical part of a criminal investigation because of its ability to suggest how the crime was committed and to provide reliable origins of DNA. In contrast to current method...
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Article
Open AccessHigh-sensitivity virus and mycoplasma screening test reveals high prevalence of parvovirus B19 infection in human synovial tissues and bone marrow
Latent microorganism infection is a safety concern for the clinical application of mesenchymal stem cells (MSCs). The aim of this study is to investigate the frequencies and sensitivities of the latent virus a...
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Article
Open AccessThe human vascular endothelial cell line HUV-EC-C harbors the integrated HHV-6B genome which remains stable in long term culture
Human herpes virus 6 (HHV-6) is a common human pathogen that is most often detected in hematopoietic cells. Although human cells harboring chromosomally integrated HHV-6 can be generated in vitro, the availabi...
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Article
Open AccessStructure-based drug discovery for combating influenza virus by targeting the PA–PB1 interaction
Influenza virus infections are serious public health concerns throughout the world. The development of compounds with novel mechanisms of action is urgently required due to the emergence of viruses with resist...
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Article
Open AccessBeta-hydroxybutyrate, an endogenic NLRP3 inflammasome inhibitor, attenuates stress-induced behavioral and inflammatory responses
Neuro-inflammation has been shown to play a critical role in the development of depression. Beta-hydroxybutyrate (BHB) is a ketone body and has recently been reported to exert anti-inflammatory effects via inh...
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Article
Effects of climate change on reduction of internal bond strength of particleboard subjected to various climatic conditions in Japan
The effects of climate change on the reduction of internal bond strength (IB) of particleboard subjected to various climatic conditions in Japan were predicted. The temperature increased throughout Japan with ...
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Article
Open AccessHeart rate responses induced by acoustic tempo and its interaction with basal heart rate
Many studies have revealed the influences of music on the autonomic nervous system (ANS). Since previous studies focused on the effects of acoustic tempo on the ANS, and humans have their own physiological osc...
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Article
Probabilistic evaluation of the final moisture content of kiln-dried lumber using the bootstrap method
This paper presents a probabilistic method of evaluating the final moisture content (MC) of lumber obtained at the end of the kiln-drying process. The final MC data of three different drying tests conducted in...
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Article
Open AccessPatterning nanofibrils through the templated growth of multiple modified amyloid peptides
There has been considerable interest in the patterning of functionalized nanowires because of the potential applications of these materials to the construction of nanodevices. A variety of biomolecular buildin...
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Article
Simple separation of Torreya nucifera and Chamaecyparis obtusa wood using portable visible and near-infrared spectrophotometry: differences in light-conducting properties
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Article
Predicting internal bond strength of particleboard under outdoor exposure based on climate data: comparison of multiple linear regression and artificial neural network
The internal bond strength (IB) of a commercial particleboard put under various outdoor exposure conditions were modeled using a multiple linear regression (MLR) and an artificial neural network (ANN). The out...
