-
Article
The prediction of estimated cerebral perfusion pressure with trans-systolic time in preterm and term infants
It is important to monitor cerebral perfusion in infants because hypo- and hyperperfusion can contribute to neurological injury. This study aimed to clarify the relationship between trans-systolic time (TST) a...
-
Article
Layered plaque is associated with high levels of vascular inflammation and vulnerability in patients with stable angina pectoris
Layered plaque, a signature of previous plaque destabilization and healing, is a known predictor for rapid plaque progression; however, the mechanism of which is unknown. The aim of the current study was to co...
-
Article
Proteomics associated with coronary high-risk plaques by optical coherence tomography
Biomarkers are widely used for the diagnosis and monitoring of cardiovascular disease. However, markers for coronary high-risk plaques have not been identified. The aim of this study was to identify proteins s...
-
Article
Higher triglyceride levels are associated with the higher prevalence of layered plaques in non-culprit coronary plaques
High triglyceride (TG) levels have been recognized as a risk factor for cardiovascular events in patients with coronary artery disease (CAD). This study aimed to clarify the association between TG levels and c...
-
Article
Open AccessA novel deep learning model for a computed tomography diagnosis of coronary plaque erosion
Patients with acute coronary syndromes caused by plaque erosion might be managed conservatively without stenting. Currently, the diagnosis of plaque erosion requires an invasive imaging procedure. We sought to...
-
Article
Layered plaque and plaque volume in patients with acute coronary syndromes
Layered plaque is a signature of previous subclinical plaque destabilization and healing. Following plaque disruption, thrombus becomes organized, resulting in creation of a new layer, which might contribute t...
-
Article
Open AccessSafety and Effectiveness of Molnupiravir (LAGEVRIO®) Capsules in Japanese Patients with COVID-19: Interim Report of Post-marketing Surveillance in Japan
Molnupiravir is an oral antiviral drug that received special approval for emergency use in Japan on December 24 2021 for infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2...
-
Article
Open AccessGrowth Factor Midkine Aggravates Pulmonary Arterial Hypertension via Surface Nucleolin
Pulmonary arterial hypertension (PAH) is a progressive fatal disease caused by pulmonary arterial remodeling. Midkine regulates cell proliferation and migration, and it is induced by hypoxia, but its roles in ...
-
Article
Increased plasma xanthine oxidoreductase activity deteriorates coronary artery spasm
Increased reactive oxygen species (ROS) contributes to the development of endothelial dysfunction, which is involved in coronary artery spasm (CAS). Xanthine oxidoreductase (XOR) plays a pivotal role in produc...
-
Article
The impact of non-alcoholic fatty liver disease fibrosis score on cardiac prognosis in patients with chronic heart failure
Liver abnormalities have a strong impact on clinical outcomes in patients with heart failure (HF), and are known as cardio-hepatic syndrome. The non-alcoholic fatty liver disease (NAFLD) fibrosis score (NFS) h...
-
Article
Open AccessTherapeutic drug monitoring of ganciclovir for postnatal cytomegalovirus infection in an extremely low birth weight infant: a case report
Ganciclovir is a therapeutic choice for extremely premature infants with severe postnatal cytomegalovirus disease, but little is known about its optimal dose size and dosing interval for them.
-
Article
Additive clinical value of serum brain-derived neurotrophic factor for prediction of chronic heart failure outcome
The importance of the central nervous system in cardiovascular events has been recognized. Recently, brain-derived neurotrophic factor (BDNF), a member of the neurotrophic factor family, is involved in depress...
-
Article
Comorbid renal tubular damage and hypoalbuminemia exacerbate cardiac prognosis in patients with chronic heart failure
Renal tubular damage (RTD) and hypoalbuminemia are risks for poor prognosis in patients with chronic heart failure (CHF). Renal tubules play a pivotal role in amino acid and albumin reabsorption, which maintai...
-
Article
Open AccessImpact of serum omentin-1 levels on cardiac prognosis in patients with heart failure
Various adipokines are reported to be associated with the development of heart failure (HF) through insulin resistance and chronic inflammation. Omentin-1 is a novel adipokine and is associated with incident c...
-
Article
The formation of Kuiper-belt binaries through exchange reactions
Recent observations1,2,3,4,5,6,7,8 have revealed that an unexpectedly high fraction—a few per cent—of the trans-Neptunian objects (TNOs) that inhabit the Kuiper belt are binaries. The components have roughly equa...
-
Chapter and Conference Paper
Kiso EKBO & Centaur Survey and the Design and Implementation of the Moving Object Detection Engine
We are now carrying out a survey of Edgeworth-Kuiper Belt Objects (EKBOs) and Centaurs using the 1.05-m Schmidt telescope with a 2K CCD camera ( 2048 x 2048 pixels) at the Kiso Observatory, Japan. We call this...
-
Article
The isophote maps of the Gegenschein obtained by CCD observations
We summarize the results of our Gegenschein observations at Norikura (altitude 2876 m, Japan) in Sept. 18, 1996, and at Kiso (altitude 1130 m, Japan) in Feb. 9–14, and March 4 and 5,1997. The instrument consis...
