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Article
Open AccessEpigenetic signals associated with delirium replicated across four independent cohorts
Delirium is risky and indicates poor outcomes for patients. Therefore, it is crucial to create an effective delirium detection method. However, the epigenetic pathophysiology of delirium remains largely unknow...
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Article
Open AccessDNA methylation in the inflammatory genes after neurosurgery and diagnostic ability of post-operative delirium
The pathophysiological mechanisms of postoperative delirium (POD) are still not clear, and no reliable biomarker is available to differentiate those with and without POD. Pre- and post-surgery blood from epile...
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Article
Open AccessMortality among patients with sepsis associated with a bispectral electroencephalography (BSEEG) score
We have previously developed a bispectral electroencephalography (BSEEG) device, which was shown to be effective in detecting delirium and predicting patient outcomes. In this study we aimed to apply the BSEEG...
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Open AccessTopological data analysis (TDA) enhances bispectral EEG (BSEEG) algorithm for detection of delirium
Current methods for screening and detecting delirium are not practical in clinical settings. We previously showed that a simplified EEG with bispectral electroencephalography (BSEEG) algorithm can detect delir...
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Article
Open AccessDiscontinuation of antidepressants after remission with antidepressant medication in major depressive disorder: a systematic review and meta-analysis
A significant clinical issue encountered after a successful acute major depressive disorder (MDD) treatment is the relapse of depressive symptoms. Although continuing maintenance therapy with antidepressants i...
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Article
Open AccessBeta-hydroxybutyrate, an endogenous NLRP3 inflammasome inhibitor, attenuates anxiety-related behavior in a rodent post-traumatic stress disorder model
Accumulating evidence suggests that elevated inflammation contributes to the pathophysiology of post-traumatic stress disorder (PTSD) and that anti-inflammatory drugs might be a new treatment strategy for PTSD...
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Open AccessBeta-hydroxybutyrate, an endogenic NLRP3 inflammasome inhibitor, attenuates stress-induced behavioral and inflammatory responses
Neuro-inflammation has been shown to play a critical role in the development of depression. Beta-hydroxybutyrate (BHB) is a ketone body and has recently been reported to exert anti-inflammatory effects via inh...
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Article
Open AccessAssociation of fronto-temporal function with cognitive ability in schizophrenia
Deficits in neuropsychological performance are common in schizophrenia, but their relationship with the fronto-temporal functional abnormalities associated with this condition remains unclear. We explored the ...
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Integrating neuroimmune systems in the neurobiology of depression
The neurobiology of depression features dichotomous alterations in corticolimbic brain regions. For example, the prefrontal cortex and hippocampus exhibit neur...
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Open AccessAssociations between depressive symptoms and fronto-temporal activities during a verbal fluency task in patients with schizophrenia
Though depressive symptoms are common in patients with schizophrenia, they are often left untreated and are associated with a high relapse rate, suicidal ideation, increased mortality, reduced social adjustmen...
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Open AccessSocial cognition and prefrontal hemodynamic responses during a working memory task in schizophrenia
Social cognition is an important determinant of functional impairment in schizophrenia, but its relationship with the prefrontal functional abnormalities associated with the condition is still unclear. The pre...
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REDD1 is essential for stress-induced synaptic loss and depressive behavior
Chronic stress can lead to depression. Ronald Duman and his colleagues show that REDD1 expression is increased in the brain of patients with major depressive disorder and is upregulated in the brains of stress...
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Crystal Structures of N2,N,N8-Tri-/;-toluenesulfonyl-2,5,8-triaza[9]-paracyclophane and N2,N5,N8-Tri-p-toluenesulfonyl-14-hydroxy-15-hydroxymethyl-O14,O15’-isopropylidene-ll-methyl-2,5,8-triaza [9] (2,5)pyridinophane
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Article
Crystal Structure of N,N′-Ditosyl-O,O′-dimesyl-3,6-diazaoctane-1,8-diol
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Article
Crystal Structure of N1, N14-Dibenzyl-N5, N10, N18, N23-tetra(toluene-p-sulfonyl)-1, 5, 10, 14, 18, 23-hexaazacyclohexacosane: New 26-Membered Hexaaza-Coronand
