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  1. Article

    Open Access

    The HLA-DRB1*09:01-DQB1*03:03 haplotype is associated with the risk for late-onset Alzheimer’s disease in APOE \({{\varepsilon }}\) 4–negative Japanese adults

    Late-onset Alzheimer’s disease (LOAD) is the most common cause of dementia among those older than 65 years. The onset of LOAD is influenced by neuroinflammation. The human leukocyte antigen (HLA) system is inv...

    Daichi Shigemizu, Koya Fukunaga, Akiko Yamakawa, Mutsumi Suganuma in npj Aging (2024)

  2. Article

    Open Access

    Classification and deep-learning–based prediction of Alzheimer disease subtypes by using genomic data

    Late-onset Alzheimer’s disease (LOAD) is the most common multifactorial neurodegenerative disease among elderly people. LOAD is heterogeneous, and the symptoms vary among patients. Genome-wide association stud...

    Daichi Shigemizu, Shintaro Akiyama, Mutsumi Suganuma in Translational Psychiatry (2023)