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36,666 Result(s)
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Article
A girl with an interstitial deletion of the short arm of chromosome 3 studied with a high-resolution banding technique
A girl with delayed growth in body height and weight, retarded psychomotor development, facial dysmorphism, high-arched palate, extension defects of elbows, and a probable hearing impairment is presented. A ch...
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Article
Map**, quantitative distribution and origin of substance P- and VIP-containing nerves in the Uvea of guinea pig eye
VIP- and substance P-like immunoreactivities were found in considerable concentrations (VIP: 17.3±4.8 pmol/g, mean ± SEM; substance P:11.1±1.8 pmol/g) in the uveal portion of the guinea pig eye.d Immunocytoche...
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Article
The 11q;22q translocation: A collaborative study of 20 new cases and analysis of 110 families
Following a previous collaborative study (Fraccaro et al. 1980), 20 new cases of 11q;22q translocation are described. Twelve families were ascertained through an unbalanced carrier of the translocation and eig...
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Site-dependence of invasiveness of ECA109 human oesophageal carcinoma cells in nude mice
ECA109 human oesophageal carcinoma cells were injected either subcutaneously or intraperitoneally into BALB/CATc 1-nu/nu mice. After 23 weeks tumours were examined histologically and by scanning electron micro...
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PI LBEI and PI JHOU: two new alpha-1-antitrypsin alleles
Two new variants of alpha-1-antitrypsin were found in a Chinese population by isoelectric focusing in polyacrylamide gel. They have been named Lbei**g (PI*LBEI) and Jhouyao (PI*JHOU) respectively. With the sampl...
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Article
Geographical variability of alpha-1-antitrypsin alleles in China: A study on six Chinese populations
Alpha-1-antitrypsin phenotypes of six Chinese Han populations (20°–45°N. latitude) were determined. The frequency of allele M2 increases from North to South China. The north-south change of M2 appears to be ma...
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Humanβ:α but not γ interferon binding site is a product of the chromosome 21 interferon action gene
The binding of human interferons to their binding site(s) was measured by the amount of radioiodinated human beta Interferon (HuIFNβ) displaceable by unlabeled human beta, alpha, and gamma Interferon (HuIFNβ, .....
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Article
Alpha-1-antitrypsin types in five Chinese national minorities
The frequencies of alpha-1-antitrypsin alleles were determined for five Chinese national minorities: Uigur, Korean, Mongolian, Chuang, and Li. PI*S and PI*Z alleles are not found in the five populations studied. ...
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Article
Morphological changes of sensory CGRP-immunoreactive and sympathetic nerves in peripheral tissues following chronic denervation
The morphological relationship between sensory and sympathetic nerves was studied in tissues of the eye and the oral cavity following chronic sympathetic or sensory denervation. Immunoreactivities for calciton...
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Article
Nonspecific influx of cytotoxic T cells into influenza virus-infected lungs of mice
The influx of cytotoxic T cells into A/WSN influenza virus-infected mouse lungs was investigated by adoptive transfer with [125I]5-iodo-2′-deoxyuridine ([125I]UdR)-labeled syngeneic cells. More A/WSN virus-immune...
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Article
Clastogen-induced chromosomal breakage as a marker for first trimester prenatal diagnosis of Fanconi anemia
Using cultured trophoblast cells obtained by chorionic villus biopsy, we diagnosed Fanconi anemia (FA) in two pregnancies and excluded it in eight pregnancies at risk for the syndrome. Baseline chromosomal bre...
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Article
Effect of l-tetrahydropalmatine on dopamine release and metabolism in the rat striatum
In vivo voltammetric measurements of striatal extracellular DOPAC concentrations and of striatal DA release in combination with post-mortem analysis of striatal catechols were performed in the rat to study the...
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Article
The fiber projections from the dentate nucleus to the reticular formation of the brain stem in the rabbit
The projections from the dentate nucleus to the reticular formation of the brain stem in rabbit have been examined by means of the Fink-Heimer technique. The fibers arising from the dentate nucleus primarily p...
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Article
The cerebellar projection from the reticular formation of the brain stem in the rabbit
By retrograde transport of horseradish peroxidase the reticulocerebellar projections were examined in twenty-six rabbits.
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Article
Acceleration of brain tubulin formation in the optic lobe of the chick embryo by light stimulation
The effect of light exposure on the protein patterns of optic lobe and forebrain of the chick embryo was analysed by a high-resolution micro-two-dimensional polyacryamide gel electrophoresis and computerized q...
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Article
A comparative study on the effect of chloroquine and ammonium chloride on feeding process of Plasmodium falciparum in vitro
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Article
The kinetics of expression of individual herpes simplex virus type 1 transcripts
We have used specific single-stranded DNA probes cloned in M13 to analyze the kinetics of expression of 20 individual herpes simplex virus type 1 (HSV-1) transcripts, most of known function. The three α transc...
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Article
Regional localization of the gene coding for sphingolipid activator protein SAP-1 on human chromosome 10
Sphingolipid activator protein SAP-1 is required for the enzymatic hydrolysis of GMI ganglioside and sulfatide. The gene coding for SAP-1 was previously mapped to human chromosome 10 using monospecific antibod...
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Article
Molecular characterization of different ataxia telangiectasia T-cell clones
Using in situ chromosomal hybridization we have mapped the gene for the T-cell receptor α-chain in three different non-malignant T-cell clones occurring in ataxia telangiectasia. The constant region was transl...
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Article
Molecular basis of β thalassemia in South China
The phenotype of β thalassemia can be caused by over 40 different mutations. To set up a prenatal diagnosis program using DNA analysis, it is important to determine the type and frequency of mutation in a part...