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Article
Open AccessTargeting epigenetic features in clear cell sarcomas based on patient-derived cell lines
Clear cell sarcomas (CCSs) are translocated aggressive malignancies, most commonly affecting young adults with a high incidence of metastases and a poor prognosis. Research into the disease is more feasible wh...
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Article
Open AccessAdvances in neural organoid systems and their application in neurotoxicity testing of environmental chemicals
Due to the complex structure and function of central nervous system (CNS), human CNS in vitro modeling is still a great challenge. Neurotoxicity testing of environmental chemicals mainly depends on the traditi...
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Article
Aerobic Oxidation of 2,3,6-Trimethylphenol with Reusable Homogenized Copper Catalysts
The oxidation of 2,3,6-trimethylphenol(TMP) can produce both 2,3,5-trimethyl-1,4-benzoquinone(TMQ) and 2,3,5-trimethyl-1,4-hydroquinone(TMHQ) as important intermediates of vitamin E. With a soluble and porous p.....
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Article
Open AccesstRNA-derived fragments as novel potential biomarkers for relapsed/refractory multiple myeloma
tRNA-derived fragments have been reported to be key regulatory factors in human tumors. However, their roles in the progression of multiple myeloma remain unknown.
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Article
Open AccessBortezomib-inducible long non-coding RNA myocardial infarction associated transcript is an oncogene in multiple myeloma that suppresses miR-29b
Clinical outcomes of patients with multiple myeloma (MM) have almost doubled the overall survival over the last decade owing to the use of proteasome inhibitor such as bortezomib (BTZ). However, some patients ...
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Article
Finding New Tricks for Old Drugs: Tumoricidal Activity of Non-Traditional Antitumor Drugs
Chemotherapy, a traditional method, plays an important role in tumor therapy. Currently, common clinical antitumor drugs have several defects like poor efficacy, side effects, etc. Furthermore, develo** new ...
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Article
Sm-Nd isotopic compositions of Cambrian-Ordovician strata at the **ggangshan area in Jiangxi Province: Tectonic implications
Whole-rock Sm-Nd isotopes were investigated for Cambrian-Ordovician strata from the **ggangshan area between the Yangtze Block and Cathysia Block in South China. These strata were deposited as a greatly thick...
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Article
Molecular characterization of ataxia telangiectasia T cell clones
To delimit the 14q32.1 recurrent breakpoint of ataxia telangiectasia clones, we performed an in situ hybridization study with various probes located on the 14q32 band. We thus mapped this breakpoint between th...
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Article
Molecular characterization of ataxia telangiectasia T cell clones
We compared inversions of chromosome 14 in an ataxia telangiectasia clone and in a malignant T cell line (SUPT1). The R-banding chromosome analysis showed a clear difference between the distal breakpoint of th...
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Article
Molecular characterization of different ataxia telangiectasia T-cell clones
Using in situ chromosomal hybridization we have mapped the gene for the T-cell receptor α-chain in three different non-malignant T-cell clones occurring in ataxia telangiectasia. The constant region was transl...
