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Article
Design and synthesis of small semi-mimetic peptides with immunomodulatory activity based on Myelin Basic Protein (MBP)
Experimental allergic encephalomyelitis (EAE) is induced in susceptible animals by immunodominant determinants of myelin basic protein (MBP). Analogs of these disease-associated peptides have been identified w...
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Article
Effect of NGF antibodies on mast cell distribution, histamine and substance P levels in the knee joint of TNF-arthritic transgenic mice
We have previously shown an increase in nerve growth factor (NGF) levels and in mast cell (MC) distribution in the synovium of patients affected by rheumatoid arthritis. We now report that purified NGF antibod...
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Article
The regulatory peptide system of the large bowel in equine grass sickness
In recent years, distinct changes in regulatory peptides have been found in a number of gastrointestinal diseases. Grass sickness is a fatal disease of horses for which the etiology has yet to be fully ascerta...
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Article
Map**, quantitative distribution and origin of substance P- and VIP-containing nerves in the Uvea of guinea pig eye
VIP- and substance P-like immunoreactivities were found in considerable concentrations (VIP: 17.3±4.8 pmol/g, mean ± SEM; substance P:11.1±1.8 pmol/g) in the uveal portion of the guinea pig eye.d Immunocytoche...
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Article
Distinct subpopulations of enteric p-type neurones contain substance P and vasoactive intestinal polypeptide
Enteric nerve profiles ultrastructurally distinct from the adrenergic and cholinergic types have been recognized for more than a decade1. Baumgarten and his colleagues2 called these neurones p-type (peptidergic) ...
