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Notch mediates the glycolytic switch via PI3K/Akt signaling to support embryonic development
BackgroundEnergy metabolism disorder or insufficient energy supply during incubation will affect the development and survival of avian embryos....
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Repeated sleep deprivation decreases the flux into hexosamine biosynthetic pathway/O-GlcNAc cycling and aggravates Alzheimer’s disease neuropathology in adult zebrafish
This study investigated chronic and repeated sleep deprivation (RSD)-induced neuronal changes in hexosamine biosynthetic pathway/ O -linked...
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Regulation of gene expression by the APP family in the adult cerebral cortex
Amyloid precursor protein (APP) is associated with both familial and sporadic forms of Alzheimer’s disease. APP has two homologs, amyloid...
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Evolutionary History of Alzheimer Disease-Causing Protein Family Presenilins with Pathological Implications
Presenilin proteins make the catalytic component of γ-secretase, a multiprotein transmembrane protease, and are type II transmembrane proteins....
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Gene-Based Management of Alzheimer’s Disease: Role of Coumarins of Ferulago Genus
The genus Ferulago, from the Apiaceae (Umbelliferae) family, comprised perennial herbs that have long been used as medicinal plants in different...
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Therapy sculpts the complex interplay between cancer and the immune system during tumour evolution
Cancer development is an evolutionary process. A key selection pressure is exerted by therapy, one of the few players in cancer evolution that can be...
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Clarity on the blazing trail: clearing the way for amyloid-removing therapies for Alzheimer’s disease
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder with a complex pathogenesis. Senile plaques composed of the amyloid-β (Aβ)...
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Gut microbiota-host lipid crosstalk in Alzheimer’s disease: implications for disease progression and therapeutics
Trillions of intestinal bacteria in the human body undergo dynamic transformations in response to physiological and pathological changes. Alterations...
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Accumulation of amyloid precursor protein C-terminal fragments triggers mitochondrial structure, function, and mitophagy defects in Alzheimer’s disease models and human brains
Several lines of recent evidence indicate that the amyloid precursor protein-derived C-terminal fragments (APP-CTFs) could correspond to an...
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Regulation of the hippocampal translatome by Apoer2-ICD release
BackgroundApoE4, the most significant genetic risk factor for late-onset Alzheimer’s disease (AD), sequesters a pro-synaptogenic Reelin receptor,...
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Sample Preparation for Electron Cryo-Microscopy of Macromolecular Machines
High-resolution structure determination by electron cryo-microscopy underwent a step change in recent years. This now allows study of challenging...
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The interaction between autophagy and the epithelial-mesenchymal transition mediated by NICD/ULK1 is involved in the formation of diabetic cataracts
BackgroundCataracts are the leading cause of blindness and a common ocular complication of diabetes. The epithelial-mesenchymal transition (EMT) of...
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Inhibition of mitochondrial complex I reverses NOTCH1-driven metabolic reprogramming in T-cell acute lymphoblastic leukemia
T-cell acute lymphoblastic leukemia (T-ALL) is commonly driven by activating mutations in NOTCH1 that facilitate glutamine oxidation. Here we...
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Glycogen Synthase Kinase-3β, NLRP3 Inflammasome, and Alzheimer’s Disease
Alzheimer’s disease (AD) is the most prevalent cause of dementia worldwide. Because of the progressive neurodegeneration, individual cognitive and...
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β-Secretase as a Primary Drug Target of Alzheimer Disease: Function, Structure, and Inhibition
β-secretase (BACE1) is responsible for regulating different biological functions. Several biochemical studies reported that BACE1 enzyme plays a key...
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Unravelling the Untapped Pharmacological Potential of Plant Molecules as Inhibitors of BACE1: In Silico Explorations for Alzheimer’s Disease
Alzheimer’s disease (AD) is an extremely complex, heterogeneous, and multifactorial neurodegenerative disease clinically characterized by progressive...
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Modeling Notch Activity and Lineage Decisions Using Intestinal Organoids
Organoid cultures have been developed to model intestinal stem cell (ISC) function in self-renewal and differentiation. Upon differentiation, the...
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Herbal Medicines for Management of Alzheimer’s Disease
The advancements in the therapeutic world have increased the average life expectancy of man, thereby causing an increase in the prevalence of...
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Recent Advances in Computational Modeling of Multi-targeting Inhibitors as Anti-Alzheimer Agents
Alzheimer’s disease (AD) is a neurodegenerative illness that affects the brain and is linked to cognitive decline, memory problems, and behavioral...