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A novel oncolytic adenovirus inhibits hepatocellular carcinoma growth
ObjectiveTo evaluate the inhibitory role of a novel oncolytic adenovirus (OA), GP73-SphK1sR-Ad5, on the growth of hepatocellular carcinoma (HCC).
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On the necessity of an integrative approach to understand protein structural dynamics
Proteins are dynamic, fluctuating between multiple conformational states. Protein dynamics, spanning orders of magnitude in time and space, allow...
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Comprehensive therapeutics targeting the corticospinal tract following spinal cord injury
Spinal cord injury (SCI), which is much in the public eye, is still a refractory disease compromising the well-being of both patients and society. In...
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Neuromodulation for tinnitus treatment: an overview of invasive and non-invasive techniques
Tinnitus is defined as a perception of sound without any external sound source. Chronic tinnitus is a frequent condition that can affect the quality...
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Transcriptional and translational responses of rapeseed leaves to red and blue lights at the rosette stage
Under different red (R):blue (B) photon flux ratios, the growth performance of rapeseed ( Brassica napus L.) is significantly different. Rapeseed...
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Adhesion of bone marrow mesenchymal stem cells on porous titanium surfaces with strontium-doped hydroxyapatite coating
ObjectiveTo determine the adhesion behavior of bone marrow mesenchymal stem cells (MSCs) on a titanium surface with a nanostructured strontium-doped...
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Towards precision medicine: from quantitative imaging to radiomics
Radiology (imaging) and imaging-guided interventions, which provide multi-parametric morphologic and functional information, are playing an...
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Soil bacterial and fungal community successions under the stress of chlorpyrifos application and molecular characterization of chlorpyrifos-degrading isolates using ERIC-PCR
Chlorpyrifos is a widely used insecticide in recent years, and it will produce adverse effects on soil when applied on crops or mixed with soil. In...
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Response properties of the electrosensory neurons in hindbrain of the white sturgeon, Acipenser transmontanus
ObjectiveThe passive electrosense is a primitive sensory modality in the Chondrostei, which include sturgeon and paddlefish. Using electroreceptors,...
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Effect of neuronal excitotoxicity on Munc18-1 distribution in nuclei of rat hippocampal neuron and primary cultured neuron
ObjectiveMunc18-1 has an important role in neurotransmitter release, and controls every step in the exocytotic pathway in the central nervous system....
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Electrophysiological properties of spinal wide dynamic range neurons in neuropathic pain rats following spinal nerve ligation
ObjectiveThe present study aimed to investigate the electrophysiological properties of wide dynamic range (WDR) neurons in spinal dorsal horn of rats...
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Effects of electrical stimulation of dorsal raphe nucleus on neuronal response properties of barrel cortex layer IV neurons following long-term sensory deprivation
ObjectiveTo evaluate the effect of electrical stimulation of dorsal raphe nucleus (DRN) on response properties of layer IV barrel cortex neurons...
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Intracellular and current source density analysis of pretectal input to the optic tectum of the frog
ObjectiveElectrophysiological examination of the ipsilateral pretectotectal projection has proved that pretectal cells elicit strong suppressive...
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Sexual dimorphism of the electrophysiological properties of the projection neurons in the robust nucleus of the arcopallium in adult zebra finches
ObjectiveTo observe the sexual differences in electrophysiological properties of neurons in the robust nucleus of the arcopallium (RA) in adult zebra...
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Response properties and receptive field organization of collision-sensitive neurons in the optic tectum of bullfrog, Rana catesbeiana
ObjectiveMany studies have reported that animals will display collision avoidance behavior when the size of retinal image of an object reaches a...
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Neuronal nociceptive responses in thalamocortical pathways
The sensation of pain is critical for the survival of animals and humans. However, the brain mechanisms underlying pain perception remain largely...
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An optimized recording method to characterize biophysical and pharmacological properties of acid-sensing ion channel
ObjectiveTo re-confirm and characterize the biophysical and pharmacological properties of endogenously expressed human acid-sensing ion channel 1a...