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Article
Open AccessElevated NRAS expression during DCIS is a potential driver for progression to basal-like properties and local invasiveness
Ductal carcinoma in situ (DCIS) is the most common type of in situ premalignant breast cancers. What drives DCIS to invasive breast cancer is unclear. Basal-like invasive breast cancers are aggressive. We have...
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Article
Open AccessInduction of N-Ras degradation by flunarizine-mediated autophagy
Ras GTPases are powerful drivers for tumorigenesis, but directly targeting Ras for treating cancer remains challenging. The growth and transforming activity of the aggressive basal-like breast cancer (BLBC) ar...
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Article
Open AccessInt6 reduction activates stromal fibroblasts to enhance transforming activity in breast epithelial cells
The INT6 gene was first discovered as a site of integration in mouse mammary tumors by the mouse mammary tumor virus; however, INT6’s role in the development of human breast cancer remains largely unknown. By gen...
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Article
Anti-estrogenic mechanism of unliganded progesterone receptor isoform B in breast cancer cells
Over half of breast cancer cases are estrogen-dependent and strategies to combat estrogen-dependent breast cancer have been to either block the activation of estrogen receptor (ER) or diminish the supply of es...
