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Article
Open AccessPeroxiredoxin 3 regulates breast cancer progression via ERK-mediated MMP-1 expression
Peroxiredoxin 3 (PRDX3), a mitochondrial hydrogen peroxide scavenger, is known to be upregulated during tumorigenesis and cancer progression. In this study, we provide evidence for the first time that PRDX3 co...
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Article
Open AccessDynamic altruistic cooperation within breast tumors
Social behaviors such as altruism, where one self-sacrifices for collective benefits, critically influence an organism’s survival and responses to the environment. Such behaviors are widely exemplified in natu...
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Article
Open AccessA three-dimensional (3D) printed simulator as a feasible assessment tool for evaluating hip arthroscopy skills
The aims of this study were (1) to develop a three-dimensional (3D) printed simulator that facilitates the simulation of surgical skills for portal placement, intra-articular identification of anatomical struc...
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A hepatocyte-targeting nanoparticle for enhanced hepatobiliary magnetic resonance imaging
Hepatobiliary magnetic resonance imaging (MRI) can inform the diagnosis of liver tumours in patients with liver cirrhosis and hepatitis. However, its clinical utility has been hampered by the lack of sensitive...
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Article
Open AccessTraining surgical skills on hip arthroscopy by simulation: a survey on surgeon’s perspectives
The purpose of this study is to investigate the importance of general and specific surgical skills for hip arthroscopy from the perspective of surgeons in China. Concurrently, we intend to identify the preferr...
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KIF21A regulates breast cancer aggressiveness and is prognostic of patient survival and tumor recurrence
Invasion of carcinoma cells into surrounding tissue affects breast cancer staging, influences choice of treatment, and impacts on patient outcome. KIF21A is a member of the kinesin superfamily that has been we...
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Breast ductal Carcinoma in situ associated with microinvasion induces immunological response and predicts ipsilateral invasive recurrence
Although microinvasion (Mi) is often thought to be an interim stage between ductal carcinoma in situ (DCIS) and established invasive ductal carcinoma, survival outcomes and biological behaviour of DCIS-Mi are ...
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Prognostic significance of phosphoglycerate dehydrogenase in breast cancer
Breast cancer is the most common type of cancer affecting women worldwide. Phosphoglycerate dehydrogenase (PHGDH) is an oxidoreductase in the serine biosynthesis pathway. Although it has been reported to affec...
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Higher density of stromal M2 macrophages in breast ductal carcinoma in situ predicts recurrence
Immune response can affect tumour progression and treatment outcome. This study investigated the potential of stromal macrophages around ductal carcinoma in situ (DCIS) in predicting recurrence and progression...
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Facilitating Small Group Learning
Small group teaching has been extensively employed in the teaching of human anatomy. Small group discussions are utilized in laboratory classes, tutorials, team-based learning, and problem-based learning. Tuto...
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Article
Prognostic role of immune infiltrates in breast ductal carcinoma in situ
Ductal carcinoma in situ (DCIS) of the breast is often regarded as a non-obligate precursor to invasive breast carcinoma but current diagnostic tools are unable to accurately predict the invasive potential of ...
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Article
A composite 3D printed model of the midcarpal joint
Three-dimensional (3D) printing has recently been developed as a resource for teaching human anatomy through the accurate reproduction of anatomical specimens. Using a composite 3D printed model with the incor...
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Article
Metabolic signatures of four major histological types of lung cancer cells
Histologically lung cancer is classified into four major types: adenocarcinoma (Ad), squamous cell carcinoma (SqCC), large cell carcinoma (LCC), and small cell lung cancer (SCLC). Presently, our understandin...
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Article
Author Correction: PTEN-L is a novel protein phosphatase for ubiquitin dephosphorylation to inhibit PINK1–Parkin-mediated mitophagy
We apologize for three errors that we just found in the paper published online on 22 June 2018.
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Article
Open AccessPTEN-L is a novel protein phosphatase for ubiquitin dephosphorylation to inhibit PINK1–Parkin-mediated mitophagy
Mitophagy is an important type of selective autophagy for specific elimination of damaged mitochondria. PTEN-induced putative kinase protein 1 (PINK1)-catalyzed phosphorylation of ubiquitin (Ub) plays a critic...
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Size and heterologous elements predict metastases in malignant phyllodes tumours of the breast
Phyllodes tumours (PTs) of the breast are uncommon fibroepithelial neoplasms comprising 0.3–1.0% of all primary breast tumours. The majority of PTs are benign and generally well managed with surgery. However, ...
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Article
Open AccessHepatic mitochondrial dysfunction is a feature of Glycogen Storage Disease Type Ia (GSDIa)
Glycogen storage disease type Ia (GSDIa, von Gierke disease) is the most common glycogen storage disorder. It is caused by the deficiency of glucose-6-phosphatase, an enzyme which catalyses the final step of g...
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Article
Open AccessYBX1 gene silencing inhibits migratory and invasive potential via CORO1C in breast cancer in vitro
Y-box binding protein-1 is an evolutionary conserved transcription and translation regulating protein that is overexpressed in various human malignancies, including breast cancer. Despite reports of YB-1 and i...
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Reference Work Entry In depth
Breast Cancer Prognostic Biomarkers
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Article
Open AccessSilver nanoparticles disrupt germline stem cell maintenance in the Drosophila testis
Silver nanoparticles (AgNPs), one of the most popular nanomaterials, are commonly used in consumer products and biomedical devices, despite their potential toxicity. Recently, AgNP exposure was reported to be ...
