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Open AccessLight-evoked deformations in rod photoreceptors, pigment epithelium and subretinal space revealed by prolonged and multilayered optoretinography
Phototransduction involves changes in concentration of ions and other solutes within photoreceptors and in subretinal space, which affect osmotic pressure and the associated water flow. Corresponding expansion...
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Open AccessMicrocrack monitoring and fracture evolution of coal and rock using integrated acoustic emission and digital image correlation techniques
The mechanical properties of a coal–rock body were examined through uniaxial compression tests, and the rupture process of the coal–rock body was monitored in real time using a combined acoustic emission (AE) ...
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Article
Open AccessEvaluating AI in medicine: a comparative analysis of expert and ChatGPT responses to colorectal cancer questions
Colorectal cancer (CRC) is a global health challenge, and patient education plays a crucial role in its early detection and treatment. Despite progress in AI technology, as exemplified by transformer-like mode...
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Article
Open AccessMechanistic insights into C-C coupling in electrochemical CO reduction using gold superlattices
Develo** in situ/operando spectroscopic techniques with high sensitivity and reproducibility is of great importance for mechanistic investigations of surface-mediated electrochemical reactions. Herein, we re...
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Article
Open AccessElucidating the structure-stability relationship of Cu single-atom catalysts using operando surface-enhanced infrared absorption spectroscopy
Understanding the structure-stability relationship of catalysts is imperative for the development of high-performance electrocatalytic devices. Herein, we utilize operando attenuated total reflectance surface-enh...
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Open AccessBland–Altman agreement analysis between CT predicted and surgical peritoneal cancer index in pseudomyxoma peritonei of appendiceal origin
Peritoneal cancer index (PCI) is the surgical variable most commonly used to quantify the extent of peritoneal metastases for pseudomyxoma peritonei (PMP) patients. The present study aimed to investigate the a...
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Open AccessHALD, a human aging and longevity knowledge graph for precision gerontology and geroscience analyses
Human aging is a natural and inevitable biological process that leads to an increased risk of aging-related diseases. Develo** anti-aging therapies for aging-related diseases requires a comprehensive underst...
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Article
Open AccessIntelligent surgical workflow recognition for endoscopic submucosal dissection with real-time animal study
Recent advancements in artificial intelligence have witnessed human-level performance; however, AI-enabled cognitive assistance for therapeutic procedures has not been fully explored nor pre-clinically validat...
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Article
Open AccessLigand activation mechanisms of human KCNQ2 channel
The human voltage-gated potassium channel KCNQ2/KCNQ3 carries the neuronal M-current, which helps to stabilize the membrane potential. KCNQ2 can be activated by analgesics and antiepileptic drugs but their act...
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Article
Open AccessAtomic high-spin cobalt(II) center for highly selective electrochemical CO reduction to CH3OH
In this work, via engineering the conformation of cobalt active center in cobalt phthalocyanine molecular catalyst, the catalytic efficiency of electrochemical carbon monoxide reduction to methanol can be dram...
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Article
Open AccessIncentive based emergency demand response effectively reduces peak load during heatwave without harm to vulnerable groups
The incentive-based emergency demand response measure serves as an important regulatory tool during energy system operations. However, whether people will sacrifice comfort to respond to it during heatwave and...
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Article
Open AccessMisdiagnosis of chronic kidney disease and parathyroid hormone testing during the past 16 years
Chronic kidney disease (CKD) is a prevalent pathological condition worldwide. Parathyroid hormone (PTH) is an important index related to bone metabolism in CKD patients and has not received enough attention. T...
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Article
Open AccessSpatially controlled construction of assembloids using bioprinting
The biofabrication of three-dimensional (3D) tissues that recapitulate organ-specific architecture and function would benefit from temporal and spatial control of cell-cell interactions. Bioprinting, while pot...
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Article
Open AccessHierarchical triphase diffusion photoelectrodes for photoelectrochemical gas/liquid flow conversion
Photoelectrochemical device is a versatile platform for achieving various chemical transformations with solar energy. However, a grand challenge, originating from mass and electron transfer of triphase—reagent...
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Article
Open AccessMicrofibrillar-associated protein 5 suppresses adipogenesis by inhibiting essential coactivator of PPARγ
Femoral head necrosis is responsible for severe pain and its incidence is increasing. Abnormal adipogenic differentiation and fat cell hypertrophy of bone marrow mesenchymal stem cells increase intramedullary ...
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Open AccessAuthor Correction: The weather affects air conditioner purchases to fill the energy efficiency gap
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Open AccessA meta-analysis of the relationship between bullying and non-suicidal self-injury among children and adolescents
Non-suicidal self-injury (NSSI) has attracted increasing attention due to its high detection rate, high risk and high repeatability. There is a need for the early identification of preventable occurrence facto...
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Open AccessThe weather affects air conditioner purchases to fill the energy efficiency gap
Energy efficiency improvement is often hindered by the energy efficiency gap. This paper examines the effect of short-run temperature fluctuations on the Energy Star air conditioner purchases in the United Sta...
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Open AccessEfficacy and safety of radiofrequency ablation versus parathyroidectomy for secondary hyperparathyroidism in dialysis patients: a single-center retrospective study
We compared the efficacy and safety of ultrasound (US)-guided radiofrequency ablation (RFA) and parathyroidectomy (PTX) for the treatment of secondary hyperparathyroidism (SHPT). In this single-center retrospe...
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Open AccessThe unconventional activation of the muscarinic acetylcholine receptor M4R by diverse ligands
Muscarinic acetylcholine receptors (mAChRs) respond to the neurotransmitter acetylcholine and play important roles in human nervous system. Muscarinic receptor 4 (M4R) is a promising drug target for treating n...