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Open AccessSystematic single-cell analysis reveals dynamic control of transposable element activity orchestrating the endothelial-to-hematopoietic transition
The endothelial-to-hematopoietic transition (EHT) process during definitive hematopoiesis is highly conserved in vertebrates. Stage-specific expression of transposable elements (TEs) has been detected during z...
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Article
Open AccessHALD, a human aging and longevity knowledge graph for precision gerontology and geroscience analyses
Human aging is a natural and inevitable biological process that leads to an increased risk of aging-related diseases. Develo** anti-aging therapies for aging-related diseases requires a comprehensive underst...
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Article
Open AccessGenomic insight into domestication of rubber tree
Understanding the genetic basis of rubber tree (Hevea brasiliensis) domestication is crucial for further improving natural rubber production to meet its increasing demand worldwide. Here we provide a high-quality...
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Article
Open AccessThe inflammatory cytokine IL-6 induces FRA1 deacetylation promoting colorectal cancer stem-like properties
Colorectal cancer (CRC) has long been known for its tight association with chronic inflammation, thought to play a key role in tumor onset and malignant progression through the modulation of cancer stemness. H...
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Network and Pathway-Based Analyses of Genes Associated with Parkinson’s Disease
Parkinson’s disease (PD) is a major neurodegenerative disease influenced by both genetic and environmental factors. Although previous studies have provided insights into the significant impacts of genetic fact...
