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Chapter and Conference Paper
Effects of Hub Bearing Integrated with Additional Wheel Steering System on Vehicle Agility and Stability
The hub-steer system by which the additional front wheel steer of the vehicle is avail-able with no modification of the external layout configurations of the existing steering and suspension systems has been d...
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Chapter and Conference Paper
Evaluation of Frequency Response Characteristics on “g-g” Planes by Using Quasi-steady State Analysis
This study investigates a methodology to visualize the representative motion characteristics with consideration of running conditions, as well as the quantitative effects of the fundamental specifications for ...
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Chapter and Conference Paper
Validation of Driver Model Based Handling Quality Evaluation by Cerebral Blood Flow
The objective evaluation indexes are required for the development of ever better handling quality cars. The authors have proposed the identified first order lag time constant, \( \tau_{L} \) in the driver model...
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Article
Open AccessC-SH2 point mutation converts p85β regulatory subunit of phosphoinositide 3-kinase to an anti-aging gene
Insulin interacts with the insulin receptor, and the activated receptor promotes activity of the phosphoinositide-3 kinase (PI3K) enzyme. A decrease in insulin or insulin-like growth factor 1 (IGF-1) signaling...
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Chapter and Conference Paper
Development of GVC Moment Plus Control for mass production
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Chapter and Conference Paper
A Study on Steering Reactive Torque for Steer-by-Wire Vehicle Using Driving Simulator
Steering torque effects on vehicle handling quality is investigated by a driver model based evaluation method. A driving simulator with a precise steering torque generating device is used for this experimental...
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Article
Morphological changes in the apex of pea roots during and after recovery from aluminium treatment
We investigated how the pea (Pisum sativum cv. Harunoka) root, upon return to an Al-free condition, recovers from injury caused by exposure to Al. The growing region of the root during and after treatment with Al...
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Article
Artepillin C Derived from Propolis Induces Neurite Outgrowth in PC12m3 Cells via ERK and p38 MAPK Pathways
We investigated whether artepillin C, a major component of Brazilian propolis, acts as a neurotrophic-like factor in rat PC12m3 cells, in which nerve growth factor (NGF)-induced neurite outgrowth is impaired. ...
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Article
Establishing and characterizing human periodontal ligament fibroblasts immortalized by SV40T-antigen and hTERT gene transfer
The periodontal ligament (PDL) is a highly specialized tissue connecting the cementum with the tooth socket bone and affects the life span of the tooth. However, little is known about the precise characteristi...
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Article
Immunosuppressant FK506 Induces Neurite Outgrowth in PC12 Mutant Cells with Impaired NGF-Promoted Neuritogenesis via a Novel MAP Kinase Signaling Pathway
We obtained a drug-hypersensitive PC12 mutant cell (PC12m3), in which neurite outgrowth was strongly stimulated by various drugs such as FK506, calcimycin and cAMP, under the condition of NGF treatment. The fr...
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Article
Alteration in the retinoblastoma gene associated with immortalization of human fibroblasts treated with60Co gamma rays
Genetic analysis was carried out in human fibroblasts (KMST-6) immortalized by treatment with60Co gamma rays in order to determine if any genetic change was involved in the immortal transformation of human cells....
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Chapter
Establishment and Characterization of SV40 T-Antigen Immortalized Human Liver Cells
Human liver cells derived from an embryo were transfected with SV40 early region (T) DNA and two cell lines, OUMS-21 and OUMS-22, were established. The cells of these lines were SV40 T-antigen positive, epithe...
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Chapter
Abnormal Fibroblast Aging and DNA Replication in the Werner Syndrome
Cell and DNA replicative potentials were studied in 10 strains of skin fibroblasts from unrelated patients with the Werner syndrome (WS) and in a progeric CRL 1277 strain. The lifespans of all WS strains and o...
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Chapter
DNA Interstrand Cross-linking, Repair, and SCE Mechanism in Human Cells in Special Reference to Fanconi Anemia
The relation of DNA cross-linking and repair to sister chromatid exchange (SCE) formation was studied in normal human, Fanconi anemia (FA), and xeroderma pigmentosum (XP) cells. Despite a hypersensitive lethal...
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Article
Higher inductions of twin and single sister chromatid exchanges by cross-linking agents in Fanconi's anemia cells
Twin and single sister chromatid exchanges (SCEs) induced by short treatments with mitomycin C (MC) and 4,5′,8-trimethylpsoralen (TMP)-plus-near ultraviolet light (NUV) were analyzed in colcemid-induced endore...
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Article
The location of ribosomal cistrons (rDNA) in chromosomes of the rat
In situ hybridization of 3H-labelled ribosomal RNA to the chromosomes of rat bone marrow cells revealed that clusters of ribosomal cistrons (rDNA) are located in the secondary constrictions of chromosomes No. 3 ...
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Article
Mechanism of differential Giemsa method for sister chromatids
THE 33258 Hoechst fluorescence1 and 33258 Hoechst–Giemsa2 methods for differential staining of bromodeoxy-uridine (BrdU)-incorporated chromatids are attractive because of their rapidity and high sensitivity in re...
