-
Article
Open AccessPreoperative chemoradiotherapy using tegafur/uracil, oral leucovorin, and irinotecan (TEGAFIRI) followed by oxaliplatin-based chemotherapy as total neoadjuvant therapy for locally advanced rectal cancer: the study protocol for a phase II trial
Total neoadjuvant therapy (TNT) is a novel treatment strategy that is an alternative to preoperative chemoradiotherapy (CRT) for locally advanced rectal cancer (LARC). However, an optimal protocol for TNT has ...
-
Chapter
Education, Cultural Capital, and Social Class Reproduction
Education has played a fundamental role in people’s long-held view of Japan as a meritocratic society. The post-war educational system aimed to reduce educational inequality associated with family backgrounds....
-
Article
Open AccessThe impact of CCR8+ regulatory T cells on cytotoxic T cell function in human lung cancer
Regulatory T cells (Tregs) suppress the host immune response and maintain immune homeostasis. Tregs also promote cancer progression and are involved in resistance to immune checkpoint inhibitor treatments. Rec...
-
Article
Open AccessFermentative production of enantiopure (S)-linalool using a metabolically engineered Pantoea ananatis
Linalool, an acyclic monoterpene alcohol, is extensively used in the flavor and fragrance industries and exists as two enantiomers, (S)- and (R)-linalool, which have different odors and biological properties. Lin...
-
Chapter
Demand and Direct Involvement: Chinese American and European American Preschoolers’ Perceptions of Parental Involvement in Children’s Schooling
Although studies have demonstrated that Chinese immigrant parents tend to be highly involved in their children’s education, little is known about Chinese American children’s perceptions of parental support and...
-
Article
Open AccessImmunotherapeutic potential of CD4 and CD8 single-positive T cells in thymic epithelial tumors
Indications for current immune checkpoint inhibitors are expanding and now include thymic epithelial tumors (TETs). Although clinical trials on immune checkpoint inhibitors for TETs are ongoing, a rationale ha...
-
Article
Open AccessLong-Term Outcomes of Pulmonary Resection for Lung Cancer Patients with Chronic Kidney Disease
The survival outcome in lung cancer patients with chronic kidney disease (CKD) has not been well evaluated. The aim of this study was to evaluate the survival outcomes following non-small cell lung cancer (NSC...
-
Article
Long-term outcomes and prognostic factors of pulmonary metastasectomy for osteosarcoma and soft tissue sarcoma
The prognostic factors of pulmonary metastasectomy in patients with osteosarcoma and soft tissue sarcoma remain controversial. The purpose of our analysis was to explore the prognostic factors and outcomes of ...
-
Article
Open AccessPeripheral T cell cytotoxicity predicts T cell function in the tumor microenvironment
Cancer immunotherapy, including immune checkpoint inhibitors, exerts beneficial effects in cancer patients. However, immune checkpoint inhibitors are only advantageous for a limited population of cancer patien...
-
Article
Concurrent combination of irradiation and immune checkpoint inhibitor for recurrent pleomorphic carcinoma of the lung
We report the case of a 49-year-old patient who developed brain, sternal, and spine metastases almost simultaneously after the radical resection of a yp-T4N0M0 pulmonary pleomorphic carcinoma of the right uppe...
-
Article
Open AccessNine primary malignant neoplasms-involving the esophagus, stomach, colon, rectum, prostate, and external ear canal-without microsatellite instability: a case report
Although cases of multiple primary malignant neoplasms are increasing, reports of more than three or four primary metachronous malignant neoplasms are extremely rare. Moreover, very few publications have provi...
-
Article
Open AccessSurgical resection of advanced non-small cell lung cancer after a response to EGFR-TKI: presentation of two cases and a literature review
The usefulness of residual tumor resection after epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) treatment remains unclear. We describe two patients who underwent residual tumor resection...
-
Article
Association of amphipathic lignin derivatives with cellobiohydrolase groups improves enzymatic saccharification of lignocellulosics
Amphipathic lignin derivatives (ALDs), prepared from hardwood acetic acid lignin and softwood soda lignin via coupling with a mono-epoxylated polyethylene glycol, have been reported to improve the enzymatic sa...
-
Article
Hereditary gastrointestinal cancer
Gastrointestinal (GI) cancer, including gastric and colorectal cancer, is a major cause of death worldwide. A substantial proportion of patients with GI cancer have a familial history, and several causative ge...
-
Article
Otological complications associated with hyperbaric oxygen therapy
The objective of the present study was to clarify the features of otological complications for hyperbaric oxygen therapy (HBOT) and the risk factors for these complications. We enrolled 1115 patients (776 male...
-
Article
Open AccessAdsorption and removal of strontium in aqueous solution by synthetic hydroxyapatite
Hydroxyapatite (HAP) is a main mineral constituent of bone and tooth and has an outstanding biocompatibility. HAP is a possible sorbent for heavy metals in wastewater due to its high adsorption capacity and l...
-
Article
Open AccessImpact of an energy-conserving strategy on succinate production under weak acidic and anaerobic conditions in Enterobacter aerogenes
Succinate is an important C4 building block chemical, and its production via fermentative processes in bacteria has many practical applications in the biotechnology field. One of the major goals of optimizing ...
-
Article
Retraction Note: DEAD-box RNA helicase subunits of the Drosha complex are required for processing of rRNA and a subset of microRNAs
Although we believe that the key finding and conclusions are still valid, recently detected image manipulation in the published figures undermines our full confidence in the integrity of the study. Wetherefore...
-
Chapter
Immigrant Children’s Schooling and Family Processes in Japan: Trends, Challenges, and Implications
Japan has faced educational challenges associated with diversifying immigrant students for the last few decades since the government opened up the door to unskilled migrant workers. Despite the country’s stron...
-
Article
Estimation of soil-to-plant transfer factors of radiocesium in 99 wild plant species grown in arable lands 1 year after the Fukushima 1 Nuclear Power Plant accident
One year after the deposition of radionuclides from the Fukushima 1 Nuclear Power Plant (A formal name is Fukushima Daiichi Nuclear Power Station) in March 2011, radiocesium (134Cs, 137Cs) concentrations ([Cs]) w...
