7 Result(s)
within
Yoshikatsu Koga
English
-
Article
Open Accessp70S6K/Akt dual inhibitor DIACC3010 is efficacious in preclinical models of gastric cancer alone and in combination with trastuzumab
The PI3K-Akt-mTOR (PAM) pathway is implicated in tumor progression in many tumor types, including metastatic gastric cancer (GC). The initial promise of PAM inhibitors has been unrealized in the clinic, presum...
-
Article
Open AccessHigh expression of TMEM180, a novel tumour marker, is associated with poor survival in stage III colorectal cancer
Transmembrane protein 180 (TMEM180) is a newly identified colorectal cancer (CRC)-specific molecule that is expressed very rarely in normal tissue and up-regulated under hypoxic conditions. We developed a mono...
-
Chapter
Preclinical Studies of ADC Therapy for Solid Tumors
Antibody engineering technologies that allow genetic modification of murine antibodies to produce chimeric mouse-human antibodies, or humanized antibodies, have led to the development of new therapeutic regime...
-
Article
Open AccessMolecular imaging using an anti-human tissue factor monoclonal antibody in an orthotopic glioma xenograft model
Nuclear medicine examinations for imaging gliomas have been introduced into clinical practice to evaluate the grade of malignancy and determine sampling locations for biopsies. However, these modalities have s...
-
Article
Open AccessImaging mass spectrometry for the precise design of antibody-drug conjugates
Antibody-drug conjugates (ADCs) are a class of immunotherapeutic agents that enable the delivery of cytotoxic drugs to target malignant cells. Because various cancers and tumour vascular endothelia strongly ex...
-
Article
Open AccessThe significance of microscopic mass spectrometry with high resolution in the visualisation of drug distribution
The visualisation and quantitative analysis of the native drug distribution in a pre-clinical or clinical setting are desirable for evaluating drug effects and optimising drug design. Here, using matrix-assist...
-
Article
Open AccessMutation analysis of Rad18 in human cancer cell lines and non small cell lung cancer tissues
Genetic instability is known as a cause of oncogenesis. Though Rad18 is reported to function in a post replication mismatch repair system, the relation between the status of Rad18 and human tumorigenesis has n...
