-
Article
Open Accessp70S6K/Akt dual inhibitor DIACC3010 is efficacious in preclinical models of gastric cancer alone and in combination with trastuzumab
The PI3K-Akt-mTOR (PAM) pathway is implicated in tumor progression in many tumor types, including metastatic gastric cancer (GC). The initial promise of PAM inhibitors has been unrealized in the clinic, presum...
-
Article
Open AccessExpansion of mixed immune cells using CD3/CD161 co-stimulation for the treatment of cancer
Adoptive cell transfer (ACT) is a type of personalized immunotherapy in which expanded immune cells are administered to patients with cancer. However, single-cell populations, such as killer T cells, dendritic...
-
Living Reference Work Entry In depth
Development of Next-Generation Antibody Therapeutics Using DDS and Molecular Imaging
In addition to the naked therapeutic antibodies, next-generation therapeutic antibodies have recently attracted great attention. Examples of next-generation therapeutic antibodies include armed antibodies, suc...
-
Article
Open AccessProtection from contamination by 211At, an enigmatic but promising alpha-particle-emitting radionuclide
211At, a promising alpha-particle-emitting radionuclide, can easily volatilize and contaminate the environment. To safely manage this unique alpha-particle-emitting radionuclide, we investigated the permeability ...
-
Article
Open AccessHigh expression of TMEM180, a novel tumour marker, is associated with poor survival in stage III colorectal cancer
Transmembrane protein 180 (TMEM180) is a newly identified colorectal cancer (CRC)-specific molecule that is expressed very rarely in normal tissue and up-regulated under hypoxic conditions. We developed a mono...
-
Article
Open AccessMechanism of action of a T cell-dependent bispecific antibody as a breakthrough immunotherapy against refractory colorectal cancer with an oncogenic mutation
T cell-dependent bispecific antibody (TDB)-induced T cell activation, which can eliminate tumor cells independent of MHC engagement, is expected to be a novel breakthrough immunotherapy against refractory canc...
-
Chapter
CAST Therapy
Cancer consists not only of tumor cells but also of tumor stroma. The latter has various components such as fibroblasts, mesenchymal cells, blood vessels or extracellular matrix proteins (e.g. collagen, fibron...
-
Article
Open AccessChemotherapy payload of anti-insoluble fibrin antibody-drug conjugate is released specifically upon binding to fibrin
Cancer-induced blood coagulation in human tumour generates insoluble fibrin (IF)-rich cancer stroma in which uneven monoclonal antibody (mAb) distribution reduce the potential effectiveness of mAb-mediated tre...
-
Article
Open AccessMolecular imaging using an anti-human tissue factor monoclonal antibody in an orthotopic glioma xenograft model
Nuclear medicine examinations for imaging gliomas have been introduced into clinical practice to evaluate the grade of malignancy and determine sampling locations for biopsies. However, these modalities have s...
-
Article
Open AccessImmunoregulation by IL-7R-targeting antibody-drug conjugates: overcoming steroid-resistance in cancer and autoimmune disease
Steroid-resistance is a common complication in the treatment of malignancies and autoimmune diseases. IL-7/IL-7R signaling, which regulates lymphocyte growth and survival, has been implicated in the developmen...
-
Article
Open AccessImaging mass spectrometry for the precise design of antibody-drug conjugates
Antibody-drug conjugates (ADCs) are a class of immunotherapeutic agents that enable the delivery of cytotoxic drugs to target malignant cells. Because various cancers and tumour vascular endothelia strongly ex...
-
Article
Open AccessTumour imaging by the detection of fibrin clots in tumour stroma using an anti-fibrin Fab fragment
The diagnosis of early and aggressive types of cancer is important for providing effective cancer therapy. Cancer-induced fibrin clots exist only within lesions. Previously, we developed a monoclonal antibody ...
-
Chapter
Microscopic Mass Spectrometry for the Precise Design of Drug Delivery Systems
To bring drugs formulated in drug delivery systems (DDS) successfully into the clinic, preclinical studies have to be conducted which are aimed at obtaining pharmacological data relevant to the clinical applic...
-
Article
Open AccessRole of SLC6A6 in promoting the survival and multidrug resistance of colorectal cancer
The treatment of colorectal cancer (CRC) might be improved by the identification of a signalling pathway that could be targeted with novel therapeutics. The results of this study indicate that the taurine tran...
-
Article
Open AccessThe significance of microscopic mass spectrometry with high resolution in the visualisation of drug distribution
The visualisation and quantitative analysis of the native drug distribution in a pre-clinical or clinical setting are desirable for evaluating drug effects and optimising drug design. Here, using matrix-assist...
-
Article
Open AccessDiscovery of an uncovered region in fibrin clots and its clinical significance
Despite the pathological importance of fibrin clot formation, little is known about the structure of these clots because X-ray and nuclear magnetic resonance (NMR) analyses are not applicable to insoluble prot...
-
Chapter
Cancer Stromal Targeting (CAST) Therapy and Tailored Antibody Drug Conjugate Therapy Depending on the Nature of Tumor Stroma
In spite of recent success of monoclonal antibody (mAb) drug conjugate (ADC) therapy in patients with hypervascular and special tumors recognized by a particular mAb, there are several issues to be solved for ...
-
Article
Induction and monitoring of definitive and visceral endoderm differentiation of mouse ES cells
Preparation of specific lineages at high purities from embryonic stem (ES) cells requires both selective culture conditions and markers to guide and monitor the differentiation. In this study, we distinguished...
-
Article
Quality of Life After Esophagectomy for Cancer: An Assessment Using the Questionnaire with the Face Scale
