-
Article
Thrombospondin type 1 repeat-derived C-mannosylated peptide attenuates synaptogenesis of cortical neurons induced by primary astrocytes via TGF-β
C-Mannosylation is a rare type of protein glycosylation and is reportedly critical for the proper folding and secretion of parental proteins. Still, the effects of C-mannosylation on the biological functions of t...
-
Article
Open AccessProtection from contamination by 211At, an enigmatic but promising alpha-particle-emitting radionuclide
211At, a promising alpha-particle-emitting radionuclide, can easily volatilize and contaminate the environment. To safely manage this unique alpha-particle-emitting radionuclide, we investigated the permeability ...
-
Article
Open AccessQuantification of serum C-mannosyl tryptophan by novel assay to evaluate renal function and vascular complications in patients with type 2 diabetes
C-Mannosyl tryptophan (CMW) is a unique glycosylated amino acid, and a candidate novel biomarker of renal function. In type 2 diabetes (T2D), a combination of metabolites including CMW has recently been the foc.....
-
Article
Monomeric C-mannosyl tryptophan is a degradation product of autophagy in cultured cells
C-Mannosyl tryptophan (C-Man-Trp) is a unique glycosylated amino acid present in various eukaryotes. The C-Man-Trp structure can be found as a monomeric form or a part of post-translational modifications within p...
-
Article
Open AccessA novel assay for detection and quantification of C-mannosyl tryptophan in normal or diabetic mice
C-Mannosyl tryptophan (C-Man-Trp) is a unique molecule in that an α-mannose is connected to the indole C2 carbon atom of a Trp residue via C-glycosidic linkage. Although serum C-Man-Trp may be a novel biomarke...
-
Chapter
Glycomimetics
Glycomimetics, Selectin, Sickle cell anemia, Vaso-occlusive crisis
-
Chapter
Glycoengineering
Glycosynthase, Oligosaccharyl transfer, Homogeneous glycoproteins
-
Chapter
CAST Therapy
Cancer consists not only of tumor cells but also of tumor stroma. The latter has various components such as fibroblasts, mesenchymal cells, blood vessels or extracellular matrix proteins (e.g. collagen, fibron...
-
Chapter
Recent Progress in Linker Technology for Antibody-Drug Conjugates: Methods for Connection and Release
Linkers connect antibodies to payloads in antibody-drug conjugates (ADCs). The choice of linker controls the conjugation-site and antibody-drug ratios as well as the releasing mechanism and the rate of release...
-
Article
Open AccessChemotherapy payload of anti-insoluble fibrin antibody-drug conjugate is released specifically upon binding to fibrin
Cancer-induced blood coagulation in human tumour generates insoluble fibrin (IF)-rich cancer stroma in which uneven monoclonal antibody (mAb) distribution reduce the potential effectiveness of mAb-mediated tre...
-
Article
Enrichment and characterization of a bacterial mixture capable of utilizing C-mannosyl tryptophan as a carbon source
C-Mannosylation, a protein-modification found in various eukaryotes, involves the attachment of a single mannose molecule to selected tryptophan residues of proteins. Since C-mannosyl tryptophan (CMW) was detecte...
-
Article
Open AccessImmunoregulation by IL-7R-targeting antibody-drug conjugates: overcoming steroid-resistance in cancer and autoimmune disease
Steroid-resistance is a common complication in the treatment of malignancies and autoimmune diseases. IL-7/IL-7R signaling, which regulates lymphocyte growth and survival, has been implicated in the developmen...
-
Article
Open AccessImaging mass spectrometry for the precise design of antibody-drug conjugates
Antibody-drug conjugates (ADCs) are a class of immunotherapeutic agents that enable the delivery of cytotoxic drugs to target malignant cells. Because various cancers and tumour vascular endothelia strongly ex...
-
Reference Work Entry In depth
C-Mannosylation: Modification on Tryptophan in Cellular Proteins
C-Mannosylation is a unique glycosylation in which an α-mannose attaches to the indole C2 carbon atom of a tryptophan (Trp) residue to produce C-mannosyl-tryptophan. C-Mannosylation usually occurs at the first...
-
Reference Work Entry In depth
Synthesis of 1,2-cis Amino Glycoside
Pyranosides containing a 2,3-trans carbamate group exhibit high 1,2-cis selectivity in glycosylation reactions. Furthermore, they are easily anomerized from the 1,2-trans to the 1,2-cis form via endocyclic cleava...
-
Living Reference Work Entry In depth
Synthesis of 1,2-cis Aminoglycoside
Pyranosides containing a 2,3-trans carbamate group exhibit high 1,2-cis selectivity in glycosylation reactions. Furthermore, they are easily anomerized from the 1,2-trans to the 1,2-cis form via endocyclic cleava...
-
Living Reference Work Entry In depth
C-Mannosylation: A Modification on Tryptophan in Cellular Proteins
C-Mannosylation is a unique glycosylation in which an α-mannose attaches to the indole C2 carbon atom of a tryptophan (Trp) residue to produce C-mannosyl-tryptophan. C-Mannosylation usually occurs at the first...
-
Article
Open AccessDiscovery of an uncovered region in fibrin clots and its clinical significance
Despite the pathological importance of fibrin clot formation, little is known about the structure of these clots because X-ray and nuclear magnetic resonance (NMR) analyses are not applicable to insoluble prot...
-
Chapter
Cancer Stromal Targeting (CAST) Therapy and Tailored Antibody Drug Conjugate Therapy Depending on the Nature of Tumor Stroma
In spite of recent success of monoclonal antibody (mAb) drug conjugate (ADC) therapy in patients with hypervascular and special tumors recognized by a particular mAb, there are several issues to be solved for ...
-
Chapter
Synthesis of Enediyne Antibiotic Oligosaccharides
A structurally novel class of antitumor natural products called enediyne antibiotics including calicheamicin, esperamicin, dynemicin A, neocardinostatin, kedarcidin, C-1027, maduropeptin, and nazmenamicin is a...
