13 Result(s)
within
Yaoxing **ao
Biomedicine
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Article
The role of a mutant CCR5 allele in HIV–1 transmission and disease progression
A 32–nucleotide deletion (δ32) within the β–chemokine receptor 5 (CCR5) gene has been described in subjects who remain uninfected despite extensive exposure to HIV–1. This allele was found to be common in the ...
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Article
A chemokine receptor CCR2 allele delays HIV-1 disease progression and is associated with a CCR5 promoter mutation
Viral and host factors influence the rate of HIV-1 disease progression1. For HIV-1 to fuse, a CD4+ cell must express a co-receptor that the virus can use2,3. The chemokine receptors CCR5 and CXCR4 are used by ...
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Chapter and Conference Paper
Distribution and Morphological Features of the Retinal Ganglion Cells in Chicks
Birds have a highly specialized visual system that produces a unique visual activity, especially in the visuomotor function. Although the avian visual system has been studied from various aspects, relatively f...
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Article
RNAi-mediated gene silencing of vascular endothelial growth factor-C inhibits tumor lymphangiogenesis and growth of gastric cancer in vivo in mice
Overexpression of vascular endothelial growth factor-C (VEGF-C) has been implicated as a critical molecular signal in tumor development by promoting intratumoral lymphangiogenesis. The aim of this study was to...
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Article
Open AccessExpression of MACC1 and c-Met in human gastric cancer and its clinical significance
Recent studies have suggested that the metastasis-associated colon cancer1 (MACC1) gene can promote tumor proliferation, invasion and metastasis through an upregulation of c-Met expression. However, its role i...
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Article
Physiological crosstalk between the AC/PKA and PLC/PKC pathways modulates melatonin-mediated, monochromatic-light-induced proliferation of T-lymphocytes in chickens
Previous study has demonstrated that melatonin plays a critical role in monochromatic-light-induced lymphocyte proliferation in response to T cell mitogen concanavalin A (ConA). However, its intracellular mech...
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Article
Open AccessHeterogeneity of PD-L1 expression in primary tumors and paired lymph node metastases of triple negative breast cancer
Programmed cell death ligand 1 (PD-L1) is a potential predictive biomarker of the response to anti-PD-L1/anti- programmed cell death 1 (PD-1) therapy in multiple cancers, including triple negative breast cance...
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Article
Open AccessEngineering multi-specific antibodies against HIV-1
As increasing numbers of broadly neutralizing monoclonal antibodies (mAbs) against HIV-1 enter clinical trials, it is becoming evident that combinations of mAbs are necessary to block infection by the diverse ...
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Chapter
Selective Autophagy Regulates Innate Immunity Through Cargo Receptor Network
Autophagy, an evolutionarily conserved cargo degradation process, is responsible to remove superfluous and unwanted cytoplasmic materials and maintain cellular homeostasis. Autophagy can be highly selective an...
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Article
Open AccessQuercetin enhances survival and axonal regeneration of motoneurons after spinal root avulsion and reimplantation: experiments in a rat model of brachial plexus avulsion
Brachial plexus avulsion (BPA) physically involves the detachment of spinal nerve roots themselves and the associated spinal cord segment, leading to permanent paralysis of motor function of the upper limb. Ro...
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Article
Open AccessAutophagy inhibition and reactive oxygen species elimination by acetyl-CoA acetyltransferase 1 through fused in sarcoma protein to promote prostate cancer
Prostate cancer is a major health issue affecting the male population worldwide, and its etiology remains relatively unknown. As presented on the Gene Expression Profiling Interactive Analysis database, acetyl...
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Article
Open AccessGut microbiota-derived metabolites mediate the neuroprotective effect of melatonin in cognitive impairment induced by sleep deprivation
Sleep loss is a serious global health concern. Consequences include memory deficits and gastrointestinal dysfunction. Our previous research showed that melatonin can effectively improve cognitive impairment an...
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Article
Open Access5-HT attenuates chronic stress-induced cognitive impairment in mice through intestinal flora disruption
The microbiota–gut–brain axis plays an important role in the development of depression. The aim of this study was to investigate the effects of 5-HT on cognitive function, learning and memory induced by chroni...
