24 Result(s)

Article

Development of a pseudo-typed virus particle based method to determine the efficacy of virucidal agents

The ongoing Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) pandemic has highlighted the threat that viral outbreaks pose to global health. A key tool in the arsenal to prevent and control viral d...

Jordan Thomas, Farah Mughal, Kelly J. Roper, Aurelia Kotsiri… in Scientific Reports (2024)

Article

Quantifying neutralising antibody responses against SARS-CoV-2 in dried blood spots (DBS) and paired sera

The ongoing SARS-CoV-2 pandemic was initially managed by non-pharmaceutical interventions such as diagnostic testing, isolation of positive cases, physical distancing and lockdowns. The advent of vaccines has ...

Kelly J. Roper, Jordan Thomas, Wejdan Albalawi, Emily Maddocks… in Scientific Reports (2023)

Article

Streptolysin O concentration and activity is central to in vivo phenotype and disease outcome in Group A Streptococcus infection

Group A Streptoccocus (GAS) is among the most diverse of all human pathogens, responsible for a range of clinical manifestations, from mild superficial infections such as pharyngitis to serious invasive infect...

Jenny Clarke, Murielle Baltazar, Mansoor Alsahag, Stavros Panagiotou… in Scientific Reports (2021)

Article

Ebola virus antibody decay–stimulation in a high proportion of survivors

Neutralizing antibody function provides a foundation for the efficacy of vaccines and therapies^1–3. Here, using a robust in vitro Ebola virus (EBOV) pseudo-particle infection assay and a well-defined set of solid...

Charlene Adaken, Janet T. Scott, Raman Sharma, Robin Gopal, Steven Dicks… in Nature (2021)

Article

Variation around the dominant viral genome sequence contributes to viral load and outcome in patients with Ebola virus disease

Viral load is a major contributor to outcome in patients with Ebola virus disease (EVD), with high values leading to a fatal outcome. Evidence from the 2013–2016 Ebola virus (EBOV) outbreak indicated that diff...

**aofeng Dong, Jordana Munoz-Basagoiti, Natasha Y. Rickett… in Genome Biology (2020)

Article

Variant cell types and host glycoproteins influencing HIV-1 infection

William A Paxton in Retrovirology (2011)

Article

Stable HIV-1 envelope glycoprotein immune complexes as vaccine immunogens

Thijs van Montfort, Mark Melchers, Tony MM van Capel, Ester C de Jong… in Retrovirology (2011)

Article

HIV-1 disease progression is associated with bile-salt stimulated lipase (BSSL) gene polymorphism

Martijn J Stax, Neeltje A Kootstra, Angélique B van't Wout… in Retrovirology (2011)

Article

Varied sensitivity to therapy of HIV-1 strains in CD4⁺ lymphocyte sub-populations upon ART initiation

Although antiretroviral therapy (ART) has proven its success against HIV-1, the long lifespan of infected cells and viral latency prevent eradication. In this study we analyzed the sensitivity to ART of HIV-1 ...

Edwin J Heeregrave, Mark J Geels, Elly Baan… in AIDS Research and Therapy (2010)

Article

Generation of representative primary virus isolates from blood plasma after isolation of HIV-1 with CD44 MicroBeads

Infection of cell cultures with cell-free virus isolated from HIV-infected patients is notoriously difficult and results in a loss of viral variation. Here, we describe viral sequences from PBMC, U87.CD4.CCR5 ...

Marion Cornelissen, Edwin J. Heeregrave, Fokla Zorgdrager… in Archives of Virology (2010)

Article

HIV vaccine: it may take two to tango, but no party time yet

A press conference on Thursday September 24 in Bangkok, Thailand, released data that an experimental vaccine provided mild protection against HIV-1 infection. This is the first positive signal of any degree of...

Ben Berkhout, William A Paxton in Retrovirology (2009)

Article

Bile-salt stimulated lipase in human milk binds DC-SIGN and inhibits HIV-1 transmission

Martijn J Stax, Marloes A Naarding, Dave Speijer, Olle Hernell… in Retrovirology (2008)

Article

The carbohydrate at asparagine 386 on HIV-1 gp120 is not essential for protein folding and function but is involved in immune evasion

The HIV-1 envelope glycoprotein gp120, which mediates viral attachment to target cells, consists for ~50% of sugar, but the role of the individual sugar chains in various aspects of gp120 folding and function ...

Rogier W Sanders, Eelco van Anken, Alexei A Nabatov, I Marije Liscaljet… in Retrovirology (2008)

Article

Effect of chloroquine on reducing HIV-1 replication in vitro and the DC-SIGN mediated transfer of virus to CD4⁺T-lymphocytes

Chloroquine (CQ) has been shown to inhibit HIV-1 replication in vitro as well as in vivo and has been proposed to alter the glycosylation pattern of the gp120 envelope. These activities indicate that the compound...

Marloes A Naarding, Elly Baan, Georgios Pollakis, William A Paxton in Retrovirology (2007)

Article

Mechanisms of resistance to HIV infection

William A. Paxton, Richard A. Koup in Springer Seminars in Immunopathology (1997)