7 Result(s)
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Article
Open AccessAutophagy inhibition and reactive oxygen species elimination by acetyl-CoA acetyltransferase 1 through fused in sarcoma protein to promote prostate cancer
Prostate cancer is a major health issue affecting the male population worldwide, and its etiology remains relatively unknown. As presented on the Gene Expression Profiling Interactive Analysis database, acetyl...
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Article
Open AccessEngineering multi-specific antibodies against HIV-1
As increasing numbers of broadly neutralizing monoclonal antibodies (mAbs) against HIV-1 enter clinical trials, it is becoming evident that combinations of mAbs are necessary to block infection by the diverse ...
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Open AccessHeterogeneity of PD-L1 expression in primary tumors and paired lymph node metastases of triple negative breast cancer
Programmed cell death ligand 1 (PD-L1) is a potential predictive biomarker of the response to anti-PD-L1/anti- programmed cell death 1 (PD-1) therapy in multiple cancers, including triple negative breast cance...
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Open AccessExpression of MACC1 and c-Met in human gastric cancer and its clinical significance
Recent studies have suggested that the metastasis-associated colon cancer1 (MACC1) gene can promote tumor proliferation, invasion and metastasis through an upregulation of c-Met expression. However, its role i...
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Article
RNAi-mediated gene silencing of vascular endothelial growth factor-C inhibits tumor lymphangiogenesis and growth of gastric cancer in vivo in mice
Overexpression of vascular endothelial growth factor-C (VEGF-C) has been implicated as a critical molecular signal in tumor development by promoting intratumoral lymphangiogenesis. The aim of this study was to...
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Article
A chemokine receptor CCR2 allele delays HIV-1 disease progression and is associated with a CCR5 promoter mutation
Viral and host factors influence the rate of HIV-1 disease progression1. For HIV-1 to fuse, a CD4+ cell must express a co-receptor that the virus can use2,3. The chemokine receptors CCR5 and CXCR4 are used by ...
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The role of a mutant CCR5 allele in HIV–1 transmission and disease progression
A 32–nucleotide deletion (δ32) within the β–chemokine receptor 5 (CCR5) gene has been described in subjects who remain uninfected despite extensive exposure to HIV–1. This allele was found to be common in the ...
