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Article
Acetyl-CoA synthetase 2 promotes diabetic renal tubular injury in mice by rewiring fatty acid metabolism through SIRT1/ChREBP pathway
Diabetic nephropathy (DN) is characterized by chronic low-grade renal inflammatory responses, which greatly contribute to disease progression. Abnormal glucose metabolism disrupts renal lipid metabolism, leadi...
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Article
Deposition of platelet-derived microparticles in podocytes contributes to diabetic nephropathy
Diabetic nephropathy (DN) is the leading cause of end-stage renal disease in the developed world. Podocyte injury is a critical cellular event involved in the progression of DN. Our previous studies demonstrat...
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Article
Open AccessPlasma Epstein-Barr virus DNA and risk of nasopharyngeal carcinoma in a prospective seropositive population
Plasma Epstein-Barr virus (EBV) DNA is considered a biomarker for nasopharyngeal carcinoma (NPC). However, its long-term role in NPC development is unclear.
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Article
PIM-Align: A Processing-in-Memory Architecture for FM-Index Search Algorithm
Genomic sequence alignment is the most critical and time-consuming step in genomic analysis. Alignment algorithms generally follow a seed-and-extend model. Acceleration of the extension phase for sequence alig...
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Article
Gut microbiota dysbiosis-induced activation of the intrarenal renin–angiotensin system is involved in kidney injuries in rat diabetic nephropathy
Some studies have shown that gut microbiota along with its metabolites is closely associated with diabetic mellitus (DM). In this study we explored the relationship between gut microbiota and kidney injuries o...
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Article
Numerical study on the effect of thermal conduction on explosive welding interface
Thermal deposition and temperature distribution on the interface of explosive welding composites affect the formation of molten regions and the interface morphology. This study is primarily devoted to discussi...
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Article
Open AccessUrinary podocyte microparticles are associated with disease activity and renal injury in systemic lupus erythematosus
New non-invasive biomarkers are demanded to identify renal damage in various autoimmune-associated kidney diseases. Glomerular podocyte damage mediated by systemic lupus erythematosus (SLE) plays an important ...
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Article
Open AccessDevelopment of functional dendrisomes based on a single molecule of polyesterbenzylether dendrimer and their application in cancer stem cell therapy
The differentiation therapy of breast cancer stem cells (CSCs) represents a significant strategy to treat cancer, but inefficient delivery to CSCs hinders the efficacy of differentiation agents. In this work, ...
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Article
Open AccessModified balloon-stent kissing technique avoid side-branch compromise for simple true bifurcation lesions
Coronary bifurcation remains one of the most challenging lesion subsets in interventinal cardiology. Provisional stenting (PS) is the dominate technique for bifurcation lesions, but the key problem is the dete...
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Article
Interaction network analysis revealed biomarkers in myocardial infarction
Myocardial infarction (MI) is a serious heart disease. The cardiac cells of patients with MI will die due to lack of blood for a long time. In this study, we aimed to find new targets for MI diagnosis and ther...
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Article
Arsenic trioxide induces the apoptosis in vascular smooth muscle cells via increasing intracellular calcium and ROS formation
The present study was designed to investigate whether arsenic trioxide induced the apoptosis in rat mesenteric arterial smooth muscle cells (SMCs), which provides new insights into mechanisms of arsenic-relate...
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Article
Membrane Tension Modulates the Effects of Apical Cholesterol on the Renal Epithelial Sodium Channel
We used patch-clamp techniques and A6 distal nephron cells as a model to determine how cholesterol regulates the renal epithelial sodium channel (ENaC). We found that luminal methyl-β-cyclodextrin (mβCD, a cho...
