-
Article
Open AccessTobacco cessation among smokers under substance use treatment for alcohol and/or cannabis: study protocol and pilot study
Approximately 80% of people with a substance use disorder (SUD) are smokers. Starting SUD treatment offers the opportunity to also quit smoking. The ACT-ATAC project aims to identify the predictors associated ...
-
Article
Open AccessPan-cancer pervasive upregulation of 3′ UTR splicing drives tumourigenesis
Most mammalian genes generate messenger RNAs with variable untranslated regions (UTRs) that are important post-transcriptional regulators. In cancer, shortening at 3′ UTR ends via alternative polyadenylation c...
-
Article
SRSF1 mediates cytokine-induced impaired imatinib sensitivity in chronic myeloid leukemia
Patients with chronic myeloid leukemia (CML) who are treated with tyrosine kinase inhibitors (TKIs) experience significant heterogeneity regarding depth and speed of responses. Factors intrinsic and extrinsic ...
-
Article
Open AccessBCL-xL/BCL2L1 is a critical anti-apoptotic protein that promotes the survival of differentiating pancreatic cells from human pluripotent stem cells
The differentiation of human pluripotent stem cells into pancreatic cells involves cellular proliferation and apoptosis during cell fate transitions. However, their implications for establishing cellular ident...
-
Chapter
Industrial Application of Genetic Algorithms to Cost Reduction of a Wind Turbine Equipped with a Tuned Mass Damper
Design optimization has already become an important tool in industry. The benefits are clear, but several drawbacks are still present, being the main one the computational cost. The numerical simulation involv...
-
Article
Open AccessViable Mice with Extensive Gene Humanization (25-kbp) Created Using Embryonic Stem Cell/Blastocyst and CRISPR/Zygote Injection Approaches
Here, we describe an expansion of the typical DNA size limitations associated with CRISPR knock-in technology, more specifically, the physical extent to which mouse genomic DNA can be replaced with donor (in t...
-
Protocol
Informational Suppression to Probe RNA:RNA Interactions in the Context of Ribonucleoproteins: U1 and 5′ Splice-Site Base-Pairing
Informational suppression is a method to map specific RNA:RNA interactions by taking advantage of the rules of base complementarity. First, a predicted Watson-Crick base pair is broken by single-nucleotide sub...
-
Chapter
Trajectory-Based Abnormality Categorization for Learning Route Patterns in Surveillance
The recognition of abnormal behaviors in video sequences has raised as a hot topic in video understanding research. Particularly, an important challenge resides on automatically detecting abnormality. However,...
-
Chapter
Beyond the Static Camera: Issues and Trends in Active Vision
Maximizing both the area coverage and the resolution per target is highly desirable in many applications of computer vision. However, with a limited number of cameras viewing a scene, the two objectives are co...
-
Chapter and Conference Paper
Knowledge Management and e-Learning for Underground Construction Projects
This paper describes a Knowledge management system (SGAC––Active Knowledge Management System) to manage the knowledge generated in a research project. This system aims both at organising project information du...
-
Chapter and Conference Paper
Automatic Learning of Background Semantics in Generic Surveilled Scenes
Advanced surveillance systems for behavior recognition in outdoor traffic scenes depend strongly on the particular configuration of the scenario. Scene-independent trajectory analysis techniques statistically ...
-
Article
A splicing component adapted to gene silencing
U1 adaptors offer an alternative to siRNA for targeted gene knockdown.
-
Article
Recognition of atypical 5′ splice sites by shifted base-pairing to U1 snRNA
One of the key early steps in splicing is recognition of the 5′ splice site by base-pairing to the U1 small nuclear RNA. Data now indicate that U1 can shift to recognize what had been designated as atypical 5′...
-
Chapter and Conference Paper
Autonomous Virtual Agents for Performance Evaluation of Tracking Algorithms
This paper describes a framework which exploits the use of computer animation to evaluate the performance of tracking algorithms. This can be achieved in two different, complementary strategies. On the one han...
-
Article
Open AccessAntisense oligonucleotide-induced alternative splicing of the APOB mRNA generates a novel isoform of APOB
Apolipoprotein B (APOB) is an integral part of the LDL, VLDL, IDL, Lp(a) and chylomicron lipoprotein particles. The APOB pre-mRNA consists of 29 constitutively-spliced exons. APOB exists as two natural isoforms: ...
-
Chapter and Conference Paper
Development of an Ontology for the Document Management Systems for Construction
This paper describes the development of an ontology for the AEC/FM projects’ documentation management that allows the classification of the documents along the lifecycle of AEC/FM projects. This ontology is ai...
-
Chapter and Conference Paper
Semantic Annotation of Complex Human Scenes for Multimedia Surveillance
A Multimedia Surveillance System (MSS) is considered for automatically retrieving semantic content from complex outdoor scenes, involving both human behavior and traffic domains. To characterize the dynamic in...
-
Chapter and Conference Paper
Automatic Learning of Conceptual Knowledge in Image Sequences for Human Behavior Interpretation
This work describes an approach for the interpretation and explanation of human behavior in image sequences, within the context of a Cognitive Vision System. The information source is the geometrical data obtaine...
-
Chapter and Conference Paper
Natural Language Descriptions of Human Behavior from Video Sequences
This contribution addresses the generation of textual descriptions in several natural languages for evaluation of human behavior in video sequences. The problem is tackled by converting geometrical information...
-
Article
Short/branched-chain acyl-CoA dehydrogenase deficiency due to an IVS3+3A>G mutation that causes exon skip**
Short/branched-chain acyl-CoA dehydrogenase deficiency (SBCADD) is an autosomal recessive disorder of l-isoleucine catabolism. Little is known about the clinical presentation associated with this enzyme defect, a...
