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Article
Author Correction: Targeting the incretin system in obesity and type 2 diabetes mellitus
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Article
Targeting the incretin system in obesity and type 2 diabetes mellitus
Obesity and type 2 diabetes mellitus (T2DM) are widespread, non-communicable diseases that are responsible for considerable levels of morbidity and mortality globally, primarily in the form of cardiovascular d...
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Article
Open AccessAdrenal Vein Sampling: Does the Location of the Non-adrenal Venous Sample Matter?
Adrenal vein sampling (AVS) is used to lateralise and differentiate unilateral from bilateral aldosterone production in primary aldosteronism. The adrenal venous samples are standardised to a peripheral or low...
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Article
Open AccessInflammatory myofibroblastic tumour arising in the adrenal gland: a case report
Inflammatory myofibroblastic tumour arising in the adrenal gland is exceptional. As far as we are aware, there have been only three previous reports in the literature. We report a fourth case.
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Article
Open AccessMultiple tandem splicing silencer elements suppress aberrant splicing within the long exon 26 of the human Apolipoprotein B gene
Apolipoprotein B (APOB) is an integral component of the chylomicron and the atherogenic lipoproteins LDL and Lp(a). Exon 26 of the APOB pre-mRNA is unusually long at 7,572 nt and is constitutively spliced. It is ...
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Protocol
Antisense-Mediated Exon-Skip** to Induce Gene Knockdown
Exon-skip** antisense oligonucleotides (ASOs) can be used to knockdown the expression of an undesired gene or specific gene isoform. This chapter discusses the potential therapeutic applications of the techn...
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Article
‘Running on empty’
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Article
Open AccessAntisense oligonucleotide-induced alternative splicing of the APOB mRNA generates a novel isoform of APOB
Apolipoprotein B (APOB) is an integral part of the LDL, VLDL, IDL, Lp(a) and chylomicron lipoprotein particles. The APOB pre-mRNA consists of 29 constitutively-spliced exons. APOB exists as two natural isoforms: ...
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Article
Mutations in MRAP, encoding a new interacting partner of the ACTH receptor, cause familial glucocorticoid deficiency type 2
Familial glucocorticoid deficiency (FGD), or hereditary unresponsiveness to adrenocorticotropin (ACTH; OMIM 202200), is an autosomal recessive disorder resulting from resistance to the action of ACTH on the ad...