U1 adaptors offer an alternative to siRNA for targeted gene knockdown.
This is a preview of subscription content, log in via an institution to check access.
References
Castanotto, D. & Rossi, J.J. Nature 457, 426–433 (2009).
Potera, C. Nat. Biotechnol. 25, 497–499 (2007).
Goraczniak, R., Behlke, M.A. & Gunderson, S.I. Nat. Biotechnol. 27, 257–263 (2009).
Furth, P.A. et al. Mol. Cell. Biol. 14, 5278–5289 (1994).
Gunderson, S.I., Polycarpou-Schwarz, M. & Mattaj, I.W. Mol. Cell 1, 255–264 (1998).
Fortes, P. et al. Proc. Natl. Acad. Sci. USA 100, 8264–8269 (2003).
Cartegni, L. & Krainer, A.R. Nat. Struct. Biol. 10, 120–125 (2003).
Skordis, L.A. et al. Proc. Natl. Acad. Sci. USA 100, 4114–4119 (2003).
Roca, X. & Krainer, A.R. Nat. Struct. Mol. Biol. 16, 176–182 (2009).
Oberdoerffer, S. et al. Science 321, 686–691 (2008).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Roca, X., Krainer, A. A splicing component adapted to gene silencing. Nat Biotechnol 27, 250–251 (2009). https://doi.org/10.1038/nbt0309-250
Issue Date:
DOI: https://doi.org/10.1038/nbt0309-250
- Springer Nature America, Inc.
This article is cited by
-
U1 Adaptor Oligonucleotides Targeting BCL2 and GRM1 Suppress Growth of Human Melanoma Xenografts In Vivo
Molecular Therapy - Nucleic Acids (2013)