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  1. No Access

    Article

    The spontaneous mouse mutant low set ears (Lse) is caused by tandem duplication of Fgf3 and Fgf4

    The external ear develops from an organized convergence of ventrally migrating neural crest cells into the first and second branchial arches. Defects in external ear position are often symptomatic of complex s...

    Alana Luzzio, Sarah Edie, Kristina Palmer, L. Brianna Caddle… in Mammalian Genome (2023)

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    Article

    A resource of targeted mutant mouse lines for 5,061 genes

    The International Mouse Phenoty** Consortium reports the generation of new mouse mutant strains for more than 5,000 genes, including 2,850 novel null, 2,987 novel conditional-ready and 4,433 novel reporter a...

    Marie-Christine Birling, Atsushi Yoshiki, David J. Adams, Shinya Ayabe… in Nature Genetics (2021)

  3. Article

    Open Access

    Sequentially inducible mouse models reveal that Npm1 mutation causes malignant transformation of Dnmt3a-mutant clonal hematopoiesis

    Clonal hematopoiesis (CH) is a common aging-associated condition with increased risk of hematologic malignancy. Knowledge of the mechanisms driving evolution from CH to overt malignancy has been hampered by a ...

    Matthew A. Loberg, Rebecca K. Bell, Leslie O. Goodwin, Elizabeth Eudy… in Leukemia (2019)

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  4. Article

    Open Access

    Viable Mice with Extensive Gene Humanization (25-kbp) Created Using Embryonic Stem Cell/Blastocyst and CRISPR/Zygote Injection Approaches

    Here, we describe an expansion of the typical DNA size limitations associated with CRISPR knock-in technology, more specifically, the physical extent to which mouse genomic DNA can be replaced with donor (in t...

    Tiffany Leidy-Davis, Kai Cheng, Leslie O. Goodwin, Judith L. Morgan… in Scientific Reports (2018)

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    Article

    CRISPRtools: a flexible computational platform for performing CRISPR/Cas9 experiments in the mouse

    Genome editing using the CRISPR/Cas9 RNA-guided endonuclease system has rapidly become a driving force for discovery in modern biomedical research. This simple yet elegant system has been widely used to genera...

    Kevin A. Peterson, Glen L. Beane, Leslie O. Goodwin, Peter M. Kutny… in Mammalian Genome (2017)

  6. No Access

    Article

    Modulation of Rat Intestinal Nuclear Factor NF-κB by Gum Arabic

    The objective of this study was to test the hypothesis that in an animal model of cathartic-induce intestinal dysfunction the proabsorptive effects of gum arabic (GA) could be associated with modulation of nuc...

    Raul A. Wapnir, Barbara Sherry, Champa N. Codipilly… in Digestive Diseases and Sciences (2008)

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    Article

    Isolation of cell lines possessing functional and serological properties resembling those of thymocyte precursors

    Thymocytes develop from a committed haematopoietic progenitor, referred to as a prothymocyte1–4. They are uniquely capable of migrating to and restoring the thymus of a lethally irradiated host, a property which ...

    Leslie O. Goodwin, Antonio J. D. Rocha, Ross S. Basch in Nature (1986)