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Article
Find and replace: editing human genome in pluripotent stem cells
Genetic manipulation of human pluripotent stem cells (hPSCs) provides a powerful tool for modeling diseases and develo** future medicine. Recently a number of independent genome-editing techniques were devel...
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Article
Converted neural cells: induced to a cure?
Many neurodegenerative disorders such as Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS) and others often occur as a result of progressive loss of structure or function of neurons. Recently, many...
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Article
Non-viral iPSCs: a safe way for therapy?
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Article
Studies on the dam** properties of polyacrylate emulsion/hindered phenol hybrids
Organic hybrids of polyacrylate emulsion (PAE)/hindered phenol (3,5-bis(1,1-dimethylethyl)-4-hydroxybenzenepropanoic acid thiodi-2,1-ethanediyl ester, abbreviated as Irganox-1035) have been prepared in this st...
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Article
Reprogramming based gene therapy for inherited red blood cell disorders
Hematopoietic stem cell transplantation remains the only curative therapy for certain genetic diseases of the hematopoietic system, including some inheritable deficiencies in red blood cells (RBC). Recent adva...
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Article
“TET-on” pluripotency
Recent studies have uncovered a specific role of TET proteins in reprogramming somatic cells to induced pluripotent stem cells, a process where O-linked β-N-acetylglucosamine transferase may play a crucial role.
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Article
DNA methylome: Unveiling your biological age
Hannum and colleagues performed DNA methylation sequencing to examine the relationship between DNA methylome and aging rate. Notably, they succeeded in building a quantitative and reproducible model based on t...
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Open AccessTop Notch cancer stem cells by paracrine NF-κB signaling in breast cancer
Cancer stem cells are likely to play critical roles in metastasis, therapy resistance, and recurrence of hematological and solid malignancies. It is well known that the stem cell niche plays a key role for asy...
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Article
Open AccessInflammasomes in cancer: a double-edged sword
Chronic inflammatory responses have long been observed to be associated with various types of cancer and play decisive roles at different stages of cancer development. Inflammasomes, which are potent inducers ...
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Article
Open AccessROR1, an embryonic protein with an emerging role in cancer biology
Receptor tyrosine kinase-like orphan receptor 1 (ROR1) is a member of the ROR family consisting of ROR1 and ROR2. RORs contain two distinct extracellular cysteine-rich domains and one transmembrane domain. Wit...
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Open AccessCharacterization of a novel mouse model with genetic deletion of CD177
Neutrophils play an essential role in the innate immune response to infection. Neutrophils migrate from the vasculature into the tissue in response to infection. Recently, a neutrophil cell surface receptor, C...
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Article
Open AccessPTEN deficiency reprogrammes human neural stem cells towards a glioblastoma stem cell-like phenotype
PTEN is a tumour suppressor frequently mutated in many types of cancers. Here we show that targeted disruption of PTEN leads to neoplastic transformation of human neural stem cells (NSCs), but not mesenchymal ...
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Open AccessSIRT6 safeguards human mesenchymal stem cells from oxidative stress by coactivating NRF2
SIRT6 belongs to the mammalian homologs of Sir2 histone NAD+-dependent deacylase family. In rodents, SIRT6 deficiency leads to aging-associated degeneration of mesodermal tissues. It remains unknown whether human...
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Open AccessVitamin C alleviates aging defects in a stem cell model for Werner syndrome
Werner syndrome (WS) is a premature aging disorder that mainly affects tissues derived from mesoderm. We have recently developed a novel human WS model using WRN-deficient human mesenchymal stem cells (MSCs). ...
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Open AccessObesity-associated NLRC4 inflammasome activation drives breast cancer progression
Obesity is associated with an increased risk of develo** breast cancer and is also associated with worse clinical prognosis. The mechanistic link between obesity and breast cancer progression remains unclear...
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Article
Open AccessVisualization of aging-associated chromatin alterations with an engineered TALE system
Visualization of specific genomic loci in live cells is a prerequisite for the investigation of dynamic changes in chromatin architecture during diverse biological processes, such as cellular aging. However, c...
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Genetic enhancement in cultured human adult stem cells conferred by a single nucleotide recoding
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Open AccessBody fatness and mTOR pathway activation of breast cancer in the Women’s Circle of Health Study
Energy imbalance has an important role in breast cancer prognosis. Hyperactive mechanistic Target of Rapamycin (mTOR) pathway is associated with breast tumor growth, but the extent to which body fatness is ass...
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Article
Open AccessMap** the immune environment in clear cell renal carcinoma by single-cell genomics
Clear cell renal cell carcinoma (ccRCC) is one of the most immunologically distinct tumor types due to high response rate to immunotherapies, despite low tumor mutational burden. To characterize the tumor immu...
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Open AccessProteolysis-targeting chimera against BCL-XL destroys tumor-infiltrating regulatory T cells
Regulatory T cells (Tregs) play an important role in maintaining immune homeostasis and, within tumors, their upregulation is common and promotes an immunosuppressive microenvironment. Therapeutic strategies t...