6 Result(s)

Article

Deep learning enables accurate clustering with batch effect removal in single-cell RNA-seq analysis

Single-cell RNA sequencing (scRNA-seq) can characterize cell types and states through unsupervised clustering, but the ever increasing number of cells and batch effect impose computational challenges. We prese...

**angjie Li, Kui Wang, Yafei Lyu, Huize Pan, **gxiao Zhang… in Nature Communications (2020)

Article

A single-cell transcriptomic landscape of primate arterial aging

Our understanding of how aging affects the cellular and molecular components of the vasculature and contributes to cardiovascular diseases is still limited. Here we report a single-cell transcriptomic survey o...

Weiqi Zhang, Shu Zhang, Pengze Yan, Jie Ren, Moshi Song, **gyi Li… in Nature Communications (2020)

Article

SIRT6 safeguards human mesenchymal stem cells from oxidative stress by coactivating NRF2

SIRT6 belongs to the mammalian homologs of Sir2 histone NAD⁺-dependent deacylase family. In rodents, SIRT6 deficiency leads to aging-associated degeneration of mesodermal tissues. It remains unknown whether human...

Huize Pan, Di Guan, **aomeng Liu, **gyi Li, Lixia Wang, Jun Wu… in Cell Research (2016)

Article

A widely adaptable approach to generate integration-free iPSCs from non-invasively acquired human somatic cells

Zhichao Ding, Lina Sui, Ruotong Ren, Yanjun Liu, **uling Xu, Lina Fu… in Protein & Cell (2015)

Article

Find and replace: editing human genome in pluripotent stem cells

Genetic manipulation of human pluripotent stem cells (hPSCs) provides a powerful tool for modeling diseases and develo** future medicine. Recently a number of independent genome-editing techniques were devel...

Huize Pan, Weiqi Zhang, Weizhou Zhang, Guang-Hui Liu in Protein & Cell (2011)