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Article
Effects of 3,4 - dihydroxyacetophenone (3,4-DHAP) on hypoxic pulmonary and systemic vascular response in dogs
The effects of 3,4-DHAP on hypoxic pulmonary and systemic vascular responses were studied in anaesthetized dogs. The percentage change in pulmonary vascular resistance (Δ PVR %) and that in systemic vascular r...
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Article
Both hypoxic endothelial cell conditioned medium and hypoxia elevate intracellular free calcium in pulmonary artery smooth muscle cells
By using Ca2+-sensitive fluorescent probe, Fura-2, the effects of endothelial cell-conditioned medium and hypoxia on intraceilular free calcium ([Ca2+]) in cultured pulmonary artery smooth muscle cell (PASMC) wer...
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Article
Effect of increasing biliary tract pressure on house rabbit blood dynamics in acute cholangitis of severe type
In this study 12 Japanese long ear rabbits were used as models of acute cholangitis of severe type (ACST), and also an increasing pressure apparatus of selfmade caecus to form high pressure of the biliary trac...
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Article
Effects of 3, 4-Dihydroxyacetophenone on hypoxic vasoconstriction in isolated pulmonary and basilar arterial rings
The effects of 3, 4-DHAP on hypoxic vasoconstriction response in pulmonary (PA) and basilar arterial (BA) rings of rabbits and their mechanism were compared in vitro.
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Article
Changes in cardiovascular activity during an increase in biliary tract pressure in rabbits
In order to study the mechanism of decreased blood pressure caused by an acute increase in biliary tract pressure, we observed house rabbit model of self-made caecus for changes in cardiovascular function when...
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Article
ATP evokes calcium transients in single pulmonary artery endothelial cell in primary cultures
Effects of ATP on cytosolic free calcium ([Ca2+]i) in single porcine pulmonary artery endothelial cell were studied. Using a dual-wavelength excitation microflurometry. it was found that ATP evoked a rapid transi...
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Article
Effect of hypoxia on release of vasoactive substances from cultured pulmonary arterial and aortic endothelial cells
The effect of hypoxia on the production and release of vasoactive substances from endothelial cells of pulmonary artery (PAECs) and aorta (AECs) was studied. The results indicated that the overall effect of tn...
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Article
The regulatory effect of substances released from porcine bronchial epithelial cells on hypoxic pulmonary vasoconstriction
In this study, porcine pulmonary artery segments (intact or denuded) and bronchial segments (with or without epithelium) were tested in organ bath. Hypoxia caused a bronchial epithelium dependent relaxation of...
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Article
Hypoxia increases cytosolic free calcium in porcine pulmonary arterial endothelial cells
Alteration of cytosolic free calcium ([Ca2+ 1]) in hypoxia was studied with fluorescent probe, Fura-2 in cultured porcine pulmonary arterial endothelial cells. It was found that hypoxia ca...
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Article
Effects of cigarette smoking on the function of metabolizing arachidonic acid and angiotensin I in the isolated perfused rat lungs
The effects of acute and chronic cigarette smoking on the metabolism of exogenous arachidonic acid (AA) and angiotensin I (AI) in perfused isolated rat lungs were studied. The results showed that acute cigaret...
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Article
Effects of acute ingestion of ethanol on hemodynamics and hypoxic pulmonary vasoconstriction in dogs—Role of leukotrienes
The effects of acute intragastric administration of ethanol on hemodynamics and hypoxic pulmonary vasoconstriction were studied in spontaneously breathing dogs. The dogs were given 0.5 g/kg of 10 % ethanol (v/...
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Article
Alteration in hypoxic pulmonary vasoconstriction during hypothermia in dogs
This study was performed to investigate the pulmonary vascular reactivity during hypothermia. It was found that the pulmonary vessels were more sensitive to alveolar hypoxia in hypothermic dogs, and that hypox...
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Article
Effect of cigarette smoking on hypoxic pulmonary vasoconstriction and its relation to animal species and period of smoking
The alteration in hypoxic pulmonary vasoconstriction (HPV) induced by cigarette smoking was studied in Wistar rats, piglets and in humans. The percentage change of pulmonary vascular resistance (δPVR%) and the...
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Article
Effects of dietary oils on pulmonary vascular reactivity and chronic hypoxic pulmonary hypertension in rats
The effects of dietary oils on pulmonary vasoreactivity and chronic hypoxic pulmonary hypertension were assessed in rats fed on soybean oil (SO), pig oil (PO), soybean oil plus pig oil (SP) or a regular diet (...
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Article
Der Einfluß des Rauchens auf die hypoxische pulmonale Vasokonstriktion in der isolierten Lunge der Ratte — die Rolle der Prostaglandine und Leukotriene
An isolierten perfundierten Rattenlungen wurde der Einfluß des Rauchens auf die pulmonale vaskuläre Resistenz (PVR) und auf die hypoxische pulmonale Vasokonstriktion (HPV), sowie die Rolle der Prostaglandine (...
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Article
Role of sympathetic nerve and adrenal gland in the potentiation of hypoxic pulmonary vasoconstriction during cigarette smoking
The aim of this study was to investigate the role of sympathetic nerve and adrenal gland in the changes in hemodynamics and hypoxic pulmonary vasoconstriction (HPV) induced by cigarette smoking in Wistar rats....
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Article
Effect of endotoxin on hypoxic pulmonary vasoconstriction — The role of prostaglandins and leukotrienes
In this, study, we observed the effect of endotoxemia on hypoxic pulmonary vasoconstriction (HPV) in dogs and explored roles played by prostaglandins and leukotrienes in this process. 5 μg/kg BW of E. coli end...
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Article
Effect of experimental acute hypertension of the biliary tract on hemodynamics and activity of the major splanchnic nerve in rabbits
An experimental study of the effect of acute biliary hypertension on hemodynamics and activity of the major splanchnic nerve was conducted in Japanese big ear white rabbits. A catheter with an inflatable rubbe...
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Article
Effects of cigarette smoking, hypoxia and vasoactive mediators on the production of PGI2 and TXA2 in cultured pulmonary artery endothelial cells
Effects of cigarette smoke extract (CSE) and some vasoactive mediators on the production of PGI2 and TXA2 in normoxic and hypoxic pulmonary artery endothelial cells (PAECs) in culture were studied. The production...
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Article
Effects of dietary magnesium on pulmonary vascular reactivity and chronic hypoxic pulmonary hypertension in rats
The effects of dietary magnesium (Mg) on pulmonary vascular reactivity and chronic hypoxic pulmonary hypertension were assessed in rats. The rats were fed high magnesium (H-Mg) diet or a regular diet for two m...
