Summary
The effects of acute and chronic cigarette smoking on the metabolism of exogenous arachidonic acid (AA) and angiotensin I (AI) in perfused isolated rat lungs were studied. The results showed that acute cigarette smoking did not alter the contents of 6-keto-PGF1α (the stable metabolite of PGI2) and TXB2 (the stable metabolite of TXA2) in the effluent and the increment of pulmonary artery pressure (†Ppa) caused by AA. The conversion of A I into A II was significantly increased (P<0.01), while the †Pp a, induced by A I injection was obviously decreased as compared with controls (P<0.05). After cigarette smoke exposure for 30 days, the †Pp a caused by AA or A I did, not differ from that of controls, but the contents of 6-ketoPGF1α and A II increased more markedly than those in non-smoking rats,(P< 0.05). It is suggested that acute and chronic cigarette smoking in rats can promote the lung function of converting A I into A II, chronic smoking can increase the lung function of metabolizing AA into PGI2.
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**ao-ling, Y., **an-rong, J. & Di-xun, W. Effects of cigarette smoking on the function of metabolizing arachidonic acid and angiotensin I in the isolated perfused rat lungs. Journal of Tongji Medical University 12, 201–204 (1992). https://doi.org/10.1007/BF02887849
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DOI: https://doi.org/10.1007/BF02887849