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  1. No Access

    Article

    Mesothelin-specific cell-based vaccine generates antigen-specific immunity and potent antitumor effects by combining with IL-12 immunomodulator

    Ovarian cancer is a gynecologic malignancy with a high mortality rate. In the present study, we developed a novel cell-based vaccine, Meso-VAX, to generate mesothelin antigen-specific immune responses and immu...

    M-C Chang, Y-L Chen, Y-C Chiang, T-C Chen, Y-C Tang, C-A Chen, W-Z Sun… in Gene Therapy (2016)

  2. No Access

    Article

    High-frequency PIN–PMN–PT single crystal ultrasonic transducer for imaging applications

    A high-frequency (∼60 MHz) ultrasonic transducer with a [001]-oriented 0.27Pb(In1/2Nb1/2)O3–0.45Pb(Mg1/3Nb2/3)O3–0.28PbTiO3 (PIN–PMN–PT) piezoelectric single crystal as an active element has been fabricated and c...

    Y. Chen, K. H. Lam, D. Zhou, W. F. Cheng, J. Y. Dai, H. S. Luo… in Applied Physics A (2012)

  3. No Access

    Article

    Noncarrier naked antigen-specific DNA vaccine generates potent antigen-specific immunologic responses and antitumor effects

    Genetic immunization strategies have largely focused on the use of plasmid DNA with a gene gun. However, there remains a clear need to further improve the efficiency, safety, and cost of potential DNA vaccines...

    C-A Chen, M-C Chang, W-Z Sun, Y-L Chen, Y-C Chiang, C-Y Hsieh, S M Chen… in Gene Therapy (2009)

  4. Article

    Open Access

    High mesothelin correlates with chemoresistance and poor survival in epithelial ovarian carcinoma

    The objective of this paper is to investigate the mesothelin expression level to the clinicopathological features, chemoresponse, and to the outcome of patients with epithelial ovarian carcinoma (EOC). Mesothe...

    W-F Cheng, C-Y Huang, M-C Chang, Y-H Hu, Y-C Chiang, Y-L Chen… in British Journal of Cancer (2009)

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  5. No Access

    Article

    Connective tissue growth factor linked to the E7 tumor antigen generates potent antitumor immune responses mediated by an antiapoptotic mechanism

    A novel method for generating an antigen-specific cancer vaccine and immunotherapy has emerged using a DNA vaccine. However, antigen-presenting cells (APCs) have a limited life span, which hinders their long-t...

    W-F Cheng, M-C Chang, W-Z Sun, C-N Lee, H-W Lin, Y-N Su, C-Y Hsieh… in Gene Therapy (2008)

  6. Article

    Open Access

    Human papillomaviral load changes in low-grade squamous intraepithelial lesions of the uterine cervix

    To better predict risk of progression of low-grade squamous intraepithelial lesions (LSILs) of the uterine cervix in women with human papillomavirus (HPV) infections, 294 baseline cervical specimens from women...

    C-M Ho, W-F Cheng, T-Y Chu, C-A Chen, M-H Chuang, S-F Chang… in British Journal of Cancer (2006)

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  7. No Access

    Article

    Sindbis virus replicon particles encoding calreticulin linked to a tumor antigen generate long-term tumor-specific immunity

    Alphavirus vectors have emerged as a promising strategy for the development of cancer vaccines and gene therapy applications. In this study, we used the replication-defective vaccine vector SIN replicon partic...

    W-F Cheng, C-N Lee, Y-N Su, C-Y Chai, M-C Chang, J M Polo, C-F Hung… in Cancer Gene Therapy (2006)

  8. No Access

    Article

    Hypoxia-induced apoptosis in endothelial cells and embryonic stem cells

    Background: To evaluate the influence of hypoxia and molecular events in endothelial and embryonic stem cells.

    C. N. Lee, W. F. Cheng, M. C. Chang, Y. N. Su, C. A. Chen, F. J. Hsieh in Apoptosis (2005)

  9. No Access

    Article

    CD8+ T cells, NK cells and IFN-γ are important for control of tumor with downregulated MHC class I expression by DNA vaccination

    One of the major hurdles facing cancer immunotherapy is that cancers may downregulate expression of MHC class I molecules. The development of a suitable tumor model with downregulated MHC class I expression is...

    W F Cheng, C F Hung, K Y Lin, M Ling, J Juang, L He, C T Lin, T-C Wu in Gene Therapy (2003)

  10. No Access

    Article

    Enhancement of suicidal DNA vaccine potency by linking Mycobacterium tuberculosis heat shock protein 70 to an antigen

    Naked DNA vaccines represent an attractive approach for generating antigen-specific immunity because of their stability and simplicity of delivery. There are particular concerns with DNA vaccines however, such...

    K-F Hsu, C-F Hung, W-F Cheng, L He, LA Slater, M Ling, T-C Wu in Gene Therapy (2001)

  11. No Access

    Article

    Recombinant DNA vaccines protect against tumors that are resistant to recombinant vaccinia vaccines containing the same gene

    Antigen-specific cancer immunotherapy involves the delivery of tumor-associated antigen to the host for the generation of tumor-specific immune responses and antitumor effects. We hypothesized that different d...

    C-H Chen, T-L Wang, H Ji, C-F Hung, DM Pardoll, W-F Cheng, M Ling, T-C Wu in Gene Therapy (2001)